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2018 ; 15
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English Wikipedia
Spatially extended hybrid methods: a review
#MMPMID29491179
Smith CA
; Yates CA
J R Soc Interface
2018[Feb]; 15
(139
): ä PMID29491179
show ga
Many biological and physical systems exhibit behaviour at multiple spatial,
temporal or population scales. Multiscale processes provide challenges when they
are to be simulated using numerical techniques. While coarser methods such as
partial differential equations are typically fast to simulate, they lack the
individual-level detail that may be required in regions of low concentration or
small spatial scale. However, to simulate at such an individual level throughout
a domain and in regions where concentrations are high can be computationally
expensive. Spatially coupled hybrid methods provide a bridge, allowing for
multiple representations of the same species in one spatial domain by
partitioning space into distinct modelling subdomains. Over the past 20 years,
such hybrid methods have risen to prominence, leading to what is now a very
active research area across multiple disciplines including chemistry, physics and
mathematics. There are three main motivations for undertaking this review.
Firstly, we have collated a large number of spatially extended hybrid methods and
presented them in a single coherent document, while comparing and contrasting
them, so that anyone who requires a multiscale hybrid method will be able to find
the most appropriate one for their need. Secondly, we have provided canonical
examples with algorithms and accompanying code, serving to demonstrate how these
types of methods work in practice. Finally, we have presented papers that employ
these methods on real biological and physical problems, demonstrating their
utility. We also consider some open research questions in the area of hybrid
method development and the future directions for the field.