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10.1038/nrn.2016.124 http://scihub22266oqcxt.onion/10.1038/nrn.2016.124 C5503467!5503467 !27708356     free     free     free Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27708356 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Nat+Rev+Neurosci 2016 ; 17 (11 ): 681-691 Nephropedia Template TP {{tp|p=27708356 |t=2016. Spatial genome organization and cognition |pdf=|usr=}}{{27708356 }} gab.com Text Spatial genome organization and cognition JO: Nat Rev Neurosci http://www.kidney.de/pget.php?&tw=1&pmid=27708356 #FOAvip Nonrandom chromosomal conformations, including promoter-enhancer loopings that bypass kilobases or megabases of linear genome, provide a crucial layer of transcriptional regulation and move vast amounts of non-coding sequence into the physical proximity of genes that are important for neurodevelopment, cognition and behaviour. Activity-regulated changes in the neuronal '3D genome' could govern transcriptional mechanisms associated with learning and plasticity, and loop-bound intergenic and intronic non-coding sequences have been implicated in psychiatric and adult-onset neurodegenerative disease. Recent studies have begun to clarify the roles of spatial genome organization in normal and abnormal cognition. Twit Text FOAVip Spatial genome organization and cognition ????Nat Rev Neurosci http://www.kidney.de/pget.php?&tw=1&pmid=27708356 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27708356 #FOAvip English Wikipedia <ref>{{Cite pmid|27708356 }}</ref> Spatial genome organization and cognition #MMPMID27708356 Rajarajan P ; Gil SE ; Brennand KJ ; Akbarian S Nat Rev Neurosci 2016[Nov]; 17 (11 ): 681-691 PMID27708356 show ga Nonrandom chromosomal conformations, including promoter-enhancer loopings that bypass kilobases or megabases of linear genome, provide a crucial layer of transcriptional regulation and move vast amounts of non-coding sequence into the physical proximity of genes that are important for neurodevelopment, cognition and behaviour. Activity-regulated changes in the neuronal '3D genome' could govern transcriptional mechanisms associated with learning and plasticity, and loop-bound intergenic and intronic non-coding sequences have been implicated in psychiatric and adult-onset neurodegenerative disease. Recent studies have begun to clarify the roles of spatial genome organization in normal and abnormal cognition. |Animals [MESH] |Cognition/*physiology [MESH] |DNA Methylation/*physiology [MESH] |DNA-Binding Proteins/genetics/metabolism [MESH] |Genome/*physiology [MESH] |Humans [MESH] |Neurodevelopmental Disorders/*genetics/metabolism/pathology [MESH] |Neurons/pathology/physiology [MESH]Spatial genome organization and cognition (epmc).pdf DeepDyve Pubget Overpricing