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10.1016/j.bpj.2015.05.012 http://scihub22266oqcxt.onion/10.1016/j.bpj.2015.05.012 C4472220!4472220 !26083931     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26083931 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Biophys+J 2015 ; 108 (12 ): 2912-24 Nephropedia Template TP {{tp|p=26083931 |t=2015. Spatial Control of Biochemical Modification Cascades and Pathways |pdf=|usr=}}{{26083931 }} gab.com Text Spatial Control of Biochemical Modification Cascades and Pathways JO: Biophys J http://www.kidney.de/pget.php?&tw=1&pmid=26083931 #FOAvip Information transmission in cells occurs through complex networks of proteins and genes and is relayed through cascades of biochemical modifications, which are typically studied through ordinary differential equations. However, it is becoming increasingly clear that spatial factors can strongly influence chemical information transmission in cells. In this article, we systematically disentangle the effects of space in signaling cascades. This is done by examining the effects of localization/compartmentalization and diffusion of enzymes and substrates in multiple variants of chemical modification cascades. This includes situations where the modified form of species at one stage 1) acts as an enzyme for the next stage; 2) acts as a substrate for the next stage; and 3) is involved in phosphotransfer. Our analysis reveals the multiple effects of space in signal transduction cascades. Although in some cases space plays a modulatory effect (itself of interest), in other cases, spatial regulation and control can profoundly affect the nature of information processing as a result of the subtle interplay between the patterns of localization of species, diffusion, and the nature of the modification cascades. Our results provide a platform for disentangling the role of space and spatial control in multiple cellular contexts and a basis for engineering spatial control in signaling cascades through localization/compartmentalization. Twit Text FOAVip Spatial Control of Biochemical Modification Cascades and Pathways ????Biophys J http://www.kidney.de/pget.php?&tw=1&pmid=26083931 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26083931 #FOAvip English Wikipedia <ref>{{Cite pmid|26083931 }}</ref> Spatial Control of Biochemical Modification Cascades and Pathways #MMPMID26083931 Alam-Nazki A ; Krishnan J Biophys J 2015[Jun]; 108 (12 ): 2912-24 PMID26083931 show ga Information transmission in cells occurs through complex networks of proteins and genes and is relayed through cascades of biochemical modifications, which are typically studied through ordinary differential equations. However, it is becoming increasingly clear that spatial factors can strongly influence chemical information transmission in cells. In this article, we systematically disentangle the effects of space in signaling cascades. This is done by examining the effects of localization/compartmentalization and diffusion of enzymes and substrates in multiple variants of chemical modification cascades. This includes situations where the modified form of species at one stage 1) acts as an enzyme for the next stage; 2) acts as a substrate for the next stage; and 3) is involved in phosphotransfer. Our analysis reveals the multiple effects of space in signal transduction cascades. Although in some cases space plays a modulatory effect (itself of interest), in other cases, spatial regulation and control can profoundly affect the nature of information processing as a result of the subtle interplay between the patterns of localization of species, diffusion, and the nature of the modification cascades. Our results provide a platform for disentangling the role of space and spatial control in multiple cellular contexts and a basis for engineering spatial control in signaling cascades through localization/compartmentalization. |*Cell Compartmentation [MESH] |*Protein Processing, Post-Translational [MESH] |*Signal Transduction [MESH] |Metabolome [MESH]Spatial Control of Biochemical Modification Cascades and Pathways (epmc).pdf DeepDyve Pubget Overpricing