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2017 ; 8
(ä): 15528
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Spaser as a biological probe
#MMPMID28593987
Galanzha EI
; Weingold R
; Nedosekin DA
; Sarimollaoglu M
; Nolan J
; Harrington W
; Kuchyanov AS
; Parkhomenko RG
; Watanabe F
; Nima Z
; Biris AS
; Plekhanov AI
; Stockman MI
; Zharov VP
Nat Commun
2017[Jun]; 8
(ä): 15528
PMID28593987
show ga
Understanding cell biology greatly benefits from the development of advanced
diagnostic probes. Here we introduce a 22-nm spaser (plasmonic nanolaser) with
the ability to serve as a super-bright, water-soluble, biocompatible probe
capable of generating stimulated emission directly inside living cells and animal
tissues. We have demonstrated a lasing regime associated with the formation of a
dynamic vapour nanobubble around the spaser that leads to giant spasing with
emission intensity and spectral width >100 times brighter and 30-fold narrower,
respectively, than for quantum dots. The absorption losses in the spaser enhance
its multifunctionality, allowing for nanobubble-amplified photothermal and
photoacoustic imaging and therapy. Furthermore, the silica spaser surface has
been covalently functionalized with folic acid for molecular targeting of cancer
cells. All these properties make a nanobubble spaser a promising multimodal,
super-contrast, ultrafast cellular probe with a single-pulse nanosecond
excitation for a variety of in vitro and in vivo biomedical applications.
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