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2014 ; 3
(3
): 182-190
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Sparse principal component analysis in cancer research
#MMPMID26719835
Hsu YL
; Huang PY
; Chen DT
Transl Cancer Res
2014[Jun]; 3
(3
): 182-190
PMID26719835
show ga
A critical challenging component in analyzing high-dimensional data in cancer
research is how to reduce the dimension of data and how to extract relevant
features. Sparse principal component analysis (PCA) is a powerful statistical
tool that could help reduce data dimension and select important variables
simultaneously. In this paper, we review several approaches for sparse PCA,
including variance maximization (VM), reconstruction error minimization (REM),
singular value decomposition (SVD), and probabilistic modeling (PM) approaches. A
simulation study is conducted to compare PCA and the sparse PCAs. An example
using a published gene signature in a lung cancer dataset is used to illustrate
the potential application of sparse PCAs in cancer research.