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2016 ; 55
(20
): 2985-2991
Nephropedia Template TP
Hirai H
; Midorikawa S
; Suzuki S
; Sasano H
; Watanabe T
; Satoh H
Intern Med
2016[]; 55
(20
): 2985-2991
PMID27746437
show ga
We herein present the findings of a 42-year-old woman with either adrenal
pheochromocytoma or intraadrenal paraganglioma that simultaneously secreted
somatostatin, thus mimicking insulin-dependent diabetes mellitus.
Pheochromocytoma was clinically diagnosed based on scintigraphy, elevated
catecholamine levels, and finally a histopathological analysis of resected
specimens. The patient had diabetic ketosis, requiring 40 U insulin for
treatment. Following laparoscopic adrenalectomy, insulin therapy was discontinued
and the urinary c-peptide levels changed from 5.5-9.0 to 81.3-87.0 ?g/day.
Histologically, somatostatin immunoreactivity was detected and the somatostatin
levels were elevated in the serum-like fluid obtained from the tumor. Clinicians
should be aware of the possible occurrence of simultaneous ectopic hormone
secretion in patients with pheochromocytoma.