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10.2169/internalmedicine.55.7071

http://scihub22266oqcxt.onion/10.2169/internalmedicine.55.7071
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C5109567!5109567 !27746437
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suck abstract from ncbi


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pmid27746437
      Intern+Med 2016 ; 55 (20 ): 2985-2991
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  • Somatostatin-secreting Pheochromocytoma Mimicking Insulin-dependent Diabetes Mellitus #MMPMID27746437
  • Hirai H ; Midorikawa S ; Suzuki S ; Sasano H ; Watanabe T ; Satoh H
  • Intern Med 2016[]; 55 (20 ): 2985-2991 PMID27746437 show ga
  • We herein present the findings of a 42-year-old woman with either adrenal pheochromocytoma or intraadrenal paraganglioma that simultaneously secreted somatostatin, thus mimicking insulin-dependent diabetes mellitus. Pheochromocytoma was clinically diagnosed based on scintigraphy, elevated catecholamine levels, and finally a histopathological analysis of resected specimens. The patient had diabetic ketosis, requiring 40 U insulin for treatment. Following laparoscopic adrenalectomy, insulin therapy was discontinued and the urinary c-peptide levels changed from 5.5-9.0 to 81.3-87.0 ?g/day. Histologically, somatostatin immunoreactivity was detected and the somatostatin levels were elevated in the serum-like fluid obtained from the tumor. Clinicians should be aware of the possible occurrence of simultaneous ectopic hormone secretion in patients with pheochromocytoma.
  • |Adrenal Gland Neoplasms/*diagnosis/*metabolism/therapy [MESH]
  • |Adrenalectomy [MESH]
  • |Adult [MESH]
  • |C-Peptide/urine [MESH]
  • |Diabetes Mellitus, Type 1/*diagnosis [MESH]
  • |Diagnosis, Differential [MESH]
  • |Female [MESH]
  • |Humans [MESH]
  • |Hypoglycemic Agents/therapeutic use [MESH]
  • |Insulin/therapeutic use [MESH]
  • |Laparoscopy [MESH]
  • |Pheochromocytoma/*diagnosis/*metabolism/therapy [MESH]


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