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2014 ; 1842
(12 Pt B
): 2584-92
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Soluble adenylyl cyclase in health and disease
#MMPMID25064591
Schmid A
; Meili D
; Salathe M
Biochim Biophys Acta
2014[Dec]; 1842
(12 Pt B
): 2584-92
PMID25064591
show ga
The second messenger cAMP is integral for many physiological processes. Soluble
adenylyl cyclase (sAC) was recently identified as a widely expressed
intracellular source of cAMP in mammalian cells. sAC is evolutionary,
structurally, and biochemically distinct from the G-protein-responsive
transmembranous adenylyl cyclases (tmAC). The structure of the catalytic unit of
sAC is similar to tmAC, but sAC does not contain transmembranous domains,
allowing localizations independent of the membranous compartment. sAC activity is
stimulated by HCO(3)(-), CaČ? and is sensitive to physiologically relevant ATP
fluctuations. sAC functions as a physiological sensor for carbon dioxide and
bicarbonate, and therefore indirectly for pH. Here we review the physiological
role of sAC in different human tissues with a major focus on the lung. This
article is part of a Special Issue entitled: The role of soluble adenylyl cyclase
in health and disease, guest edited by J. Buck and L.R. Levin.