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2017 ; 205
(4
): 1573-1586
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Soft Selective Sweeps in Evolutionary Rescue
#MMPMID28213477
Wilson BA
; Pennings PS
; Petrov DA
Genetics
2017[Apr]; 205
(4
): 1573-1586
PMID28213477
show ga
Evolutionary rescue occurs when a population that is declining in size because of
an environmental change is rescued from extinction by genetic adaptation.
Evolutionary rescue is an important phenomenon at the intersection of ecology and
population genetics, and the study of evolutionary rescue is critical to
understanding processes ranging from species conservation to the evolution of
drug and pesticide resistance. While most population-genetic models of
evolutionary rescue focus on estimating the probability of rescue, we focus on
whether one or more adaptive lineages contribute to evolutionary rescue. We find
that when evolutionary rescue is likely, it is often driven by soft selective
sweeps where multiple adaptive mutations spread through the population
simultaneously. We give full analytic results for the probability of evolutionary
rescue and the probability that evolutionary rescue occurs via soft selective
sweeps. We expect that these results will find utility in understanding the
genetic signatures associated with various evolutionary rescue scenarios in large
populations, such as the evolution of drug resistance in viral, bacterial, or
eukaryotic pathogens.
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