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2016 ; 165
(7
): 1820-1820.e1
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SnapShot: Mechanosensing Matrix
#MMPMID27315485
Irianto J
; Pfeifer CR
; Xia Y
; Discher DE
Cell
2016[Jun]; 165
(7
): 1820-1820.e1
PMID27315485
show ga
Cells sense and respond to properties of their microenvironment that can affect
cell morphology, protein levels and localization, gene expression, and even
nuclear integrity. Tissue micro-stiffness, largely influenced by extracellular
matrix, varies dramatically within an organism and can be a useful parameter to
both clarify and organize a wide range of cell and molecular processes, such as
genomic changes in cancer.