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2017 ; 34
(8
): 1960-1973
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SmithRNAs: Could Mitochondria "Bend" Nuclear Regulation?
#MMPMID28444389
Pozzi A
; Plazzi F
; Milani L
; Ghiselli F
; Passamonti M
Mol Biol Evol
2017[Aug]; 34
(8
): 1960-1973
PMID28444389
show ga
Typically, animal mitochondria have very compact genomes, with few short
intergenic regions, and no introns. Hence, it may seem that there is little space
for unknown functions in mitochondrial DNA (mtDNA). However, mtDNA can also
operate through RNA interference, as small non coding RNAs (sncRNAs) produced by
mtDNA have already been proposed for humans. We sequenced sncRNA libraries from
isolated mitochondria of Ruditapes philippinarum (Mollusca Bivalvia) gonads, a
species with doubly uniparental inheritance of mitochondria, and identified
several putative sncRNAs of mitochondrial origin. Some sncRNAs are transcribed by
intergenic regions that form stable stem-hairpin structures, which makes them
good miRNA-like candidates. We decided to name them small mitochondrial
highly-transcribed RNAs (smithRNAs). Many concurrent data support that we have
recovered sncRNAs of mitochondrial origin that might be involved in gonad
formation and able to affect nuclear gene expression. This possibility has been
never suggested before. If mtDNA can affect nuclear gene expression through RNA
interference, this opens a plethora of new possibilities for it to interact with
the nucleus, and makes metazoan mtDNA a much more complex genome than previously
thought.
|Animals
[MESH]
|Base Sequence
[MESH]
|Bivalvia/*genetics
[MESH]
|DNA, Mitochondrial/genetics
[MESH]
|Gene Expression Regulation
[MESH]
|Genes, Mitochondrial/genetics
[MESH]
|Genome, Mitochondrial/genetics
[MESH]
|Gonads
[MESH]
|Inheritance Patterns/genetics
[MESH]
|Mitochondria/*genetics
[MESH]
|RNA Interference/physiology
[MESH]
|RNA, Small Untranslated/*genetics/physiology
[MESH]
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