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Smart Mesoporous Nanomaterials for Antitumor Therapy
#MMPMID28347103
Martínez-Carmona M
; Colilla M
; Vallet-Regí M
Nanomaterials (Basel)
2015[Nov]; 5
(4
): 1906-1937
PMID28347103
show ga
The use of nanomaterials for the treatment of solid tumours is receiving
increasing attention by the scientific community. Among them, mesoporous silica
nanoparticles (MSNs) exhibit unique features that make them suitable nanocarriers
to host, transport and protect drug molecules until the target is reached. It is
possible to incorporate different targeting ligands to the outermost surface of
MSNs to selectively drive the drugs to the tumour tissues. To prevent the
premature release of the cargo entrapped in the mesopores, it is feasible to cap
the pore entrances using stimuli-responsive nanogates. Therefore, upon exposure
to internal (pH, enzymes, glutathione, etc.) or external (temperature, light,
magnetic field, etc.) stimuli, the pore opening takes place and the release of
the entrapped cargo occurs. These smart MSNs are capable of selectively reaching
and accumulating at the target tissue and releasing the entrapped drug in a
specific and controlled fashion, constituting a promising alternative to
conventional chemotherapy, which is typically associated with undesired side
effects. In this review, we overview the recent advances reported by the
scientific community in developing MSNs for antitumor therapy. We highlight the
possibility to design multifunctional nanosystems using different therapeutic
approaches aimed at increasing the efficacy of the antitumor treatment.
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