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10.1016/j.bmcl.2015.03.012 http://scihub22266oqcxt.onion/10.1016/j.bmcl.2015.03.012 C4567957!4567957 !25813158     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=25813158 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25813158 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Bioorg+Med+Chem+Lett 2015 ; 25 (21 ): 4961-4969 Nephropedia Template TP {{tp|p=25813158 |t=2015. Small cyclic agonists of iron regulatory hormone hepcidin |pdf=|usr=}}{{25813158 }} gab.com Text Small cyclic agonists of iron regulatory hormone hepcidin JO: Bioorg Med Chem Lett http://www.kidney.de/pget.php?&tw=1&pmid=25813158 #FOAvip Minihepcidins are in vitro and in vivo active mimetics of iron-regulatory hormone hepcidin. They contain various unusual amino acids including: N-substituted, ?-homo-, and d-amino acids with their combination depending on particular minihepcidin. In the current study, we sought to limit the use of unusual/more expensive amino acids derivatives by peptide cyclization. Novel cyclic mimetics of hepcidin were synthesized and tested in vitro and showed activity at low nanomolar concentration. Nonetheless, the most active cyclic compound (mHS17) is approximately ten times less active than the parental minihepcidin PR73. Collectively, our findings suggest that cyclization is viable approach in the synthesis of hepcidin mimetics. Twit Text FOAVip Small cyclic agonists of iron regulatory hormone hepcidin ????Bioorg Med Chem Lett http://www.kidney.de/pget.php?&tw=1&pmid=25813158 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25813158 #FOAvip English Wikipedia <ref>{{Cite pmid|25813158 }}</ref> Small cyclic agonists of iron regulatory hormone hepcidin #MMPMID25813158 Chua K ; Fung E ; Micewicz ED ; Ganz T ; Nemeth E ; Ruchala P Bioorg Med Chem Lett 2015[Nov]; 25 (21 ): 4961-4969 PMID25813158 show ga Minihepcidins are in vitro and in vivo active mimetics of iron-regulatory hormone hepcidin. They contain various unusual amino acids including: N-substituted, ?-homo-, and d-amino acids with their combination depending on particular minihepcidin. In the current study, we sought to limit the use of unusual/more expensive amino acids derivatives by peptide cyclization. Novel cyclic mimetics of hepcidin were synthesized and tested in vitro and showed activity at low nanomolar concentration. Nonetheless, the most active cyclic compound (mHS17) is approximately ten times less active than the parental minihepcidin PR73. Collectively, our findings suggest that cyclization is viable approach in the synthesis of hepcidin mimetics. |Amino Acids/chemistry/*pharmacology [MESH] |Dose-Response Relationship, Drug [MESH] |Hepcidins/*agonists [MESH] |Humans [MESH] |Molecular Structure [MESH] |Peptides/chemical synthesis/chemistry/*pharmacology [MESH]Small cyclic agonists of iron regulatory hormone hepcidin (epmc).pdf DeepDyve Pubget Overpricing