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2013 ; 342
(6156
): 373-7
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Sleep drives metabolite clearance from the adult brain
#MMPMID24136970
Xie L
; Kang H
; Xu Q
; Chen MJ
; Liao Y
; Thiyagarajan M
; O'Donnell J
; Christensen DJ
; Nicholson C
; Iliff JJ
; Takano T
; Deane R
; Nedergaard M
Science
2013[Oct]; 342
(6156
): 373-7
PMID24136970
show ga
The conservation of sleep across all animal species suggests that sleep serves a
vital function. We here report that sleep has a critical function in ensuring
metabolic homeostasis. Using real-time assessments of tetramethylammonium
diffusion and two-photon imaging in live mice, we show that natural sleep or
anesthesia are associated with a 60% increase in the interstitial space,
resulting in a striking increase in convective exchange of cerebrospinal fluid
with interstitial fluid. In turn, convective fluxes of interstitial fluid
increased the rate of ?-amyloid clearance during sleep. Thus, the restorative
function of sleep may be a consequence of the enhanced removal of potentially
neurotoxic waste products that accumulate in the awake central nervous system.
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