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2015 ; 1
(1
): 47-54
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Sleep, Performance, and Memory in Flies
#MMPMID26120553
Dissel S
; Melnattur K
; Shaw PJ
Curr Sleep Med Rep
2015[]; 1
(1
): 47-54
PMID26120553
show ga
Drosophila has proven to be a powerful model to identify genes and circuits that
impact sleep. While the majority of studies have primarily been interested in
identifying manipulations that alter sleep time, a growing body of work has begun
to focus on how changing sleep influences functional outcomes such as cognitive
performance, structural plasticity, and metabolism to name a few. Evaluating
sleep time provides an appropriate entry point into elucidating sleep function.
However, it is not possible to fully understand how a manipulation has impacted
sleep regulation without first establishing how it has affected the animals'
well-being. Synaptic plasticity and memory are important functional outcomes that
can be used to asses an animal's status. In this manuscript, we review recent
advances in studies examining sleep, memory, and performance. We conclude that as
Drosophila sleep researchers expand their analysis beyond sleep time, the
opportunities to discover the function of sleep will be enhanced.