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2016 ; 17
(3
): 283-286
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Skin manifestations of Cushing s syndrome
#MMPMID27943005
Stratakis CA
Rev Endocr Metab Disord
2016[Sep]; 17
(3
): 283-286
PMID27943005
show ga
Among the most common diagnostic manifestations of Cushing's syndrome (CS) are
those involving the skin; they include violaceous striae, facial acne, hirsutism,
acanthosis nigricans (AN), fungal infections, hyperpigmentation (Hp) and easy
bruisability. Fortunately, most resolve within a year or two after cure of CS,
although light-colored striae can persist for years depending on the age of the
patients. AN, Hp, and bruisability usually resolve within months after cure in
almost all ages. Facial plethora (along with acne and other facial skin changes)
is a typical sign of CS that is due to increased perfusion. It resolves
immediately after curative therapy of CS. Typically, the severity of the
manifestations does not correlate with the biochemical indices of the disease,
pointing to age, gender, genetic and skin-type differences that determine the
cutaneous manifestations of CS.