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2015 ; 2015
(ä): 758148
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Skeleton and glucose metabolism: a bone-pancreas loop
#MMPMID25873957
Faienza MF
; Luce V
; Ventura A
; Colaianni G
; Colucci S
; Cavallo L
; Grano M
; Brunetti G
Int J Endocrinol
2015[]; 2015
(ä): 758148
PMID25873957
show ga
Bone has been considered a structure essential for mobility, calcium homeostasis,
and hematopoietic function. Recent advances in bone biology have highlighted the
importance of skeleton as an endocrine organ which regulates some metabolic
pathways, in particular, insulin signaling and glucose tolerance. This review
will point out the role of bone as an endocrine "gland" and, specifically, of
bone-specific proteins, as the osteocalcin (Ocn), and proteins involved in bone
remodeling, as osteoprotegerin, in the regulation of insulin function and glucose
metabolism.