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Sirtuins in glucose and lipid metabolism
#MMPMID27659520
Ye X
; Li M
; Hou T
; Gao T
; Zhu WG
; Yang Y
Oncotarget
2017[Jan]; 8
(1
): 1845-1859
PMID27659520
show ga
Sirtuins are evolutionarily conserved protein, serving as nicotinamide adenine
dinucleotide-dependent deacetylases or adenosine diphosphate-ribosyltransferases.
The mammalian sirtuins family, including SIRT1~7, is involved in many biological
processes such as cell survival, proliferation, senescence, stress response,
genome stability and metabolism. Evidence accumulated over the past two decades
has indicated that sirtuins not only serve as important energy status sensors but
also protect cells against metabolic stresses. In this review, we summarize the
background of glucose and lipid metabolism concerning sirtuins and discuss the
functions of sirtuins in glucose and lipid metabolism. We also seek to highlight
the biological roles of certain sirtuins members in cancer metabolism.