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2017 ; 30
(4
): 216-224
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Sirtuins in Skin and Skin Cancers
#MMPMID28704830
Garcia-Peterson LM
; Wilking-Busch MJ
; Ndiaye MA
; Philippe CGA
; Setaluri V
; Ahmad N
Skin Pharmacol Physiol
2017[]; 30
(4
): 216-224
PMID28704830
show ga
The sirtuins are a family of proteins that comprise class III of the histone
deacetylases. These NAD+-dependent proteins have been found to be intricately
involved in a variety of important and skin-relevant cellular functions and
processes, including aging, UV damage response, oxidative stress, and wound
repair. In addition, recent research is unraveling the role of sirtuins in a
variety of skin diseases, including melanoma and nonmelanoma skin cancers. In
this review, we provide a discussion on the potential roles and implications of
different sirtuins in skin-specific cellular processes, which may have relevance
to skin health and skin diseases. Based on the available literature, the sirtuins
appear to be important targets in the management of a variety of skin diseases
from cosmetic (e.g., skin aging) to fatal conditions (e.g., melanoma).