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10.1159/000477417

http://scihub22266oqcxt.onion/10.1159/000477417
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suck abstract from ncbi


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pmid28704830
      Skin+Pharmacol+Physiol 2017 ; 30 (4 ): 216-224
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  • Sirtuins in Skin and Skin Cancers #MMPMID28704830
  • Garcia-Peterson LM ; Wilking-Busch MJ ; Ndiaye MA ; Philippe CGA ; Setaluri V ; Ahmad N
  • Skin Pharmacol Physiol 2017[]; 30 (4 ): 216-224 PMID28704830 show ga
  • The sirtuins are a family of proteins that comprise class III of the histone deacetylases. These NAD+-dependent proteins have been found to be intricately involved in a variety of important and skin-relevant cellular functions and processes, including aging, UV damage response, oxidative stress, and wound repair. In addition, recent research is unraveling the role of sirtuins in a variety of skin diseases, including melanoma and nonmelanoma skin cancers. In this review, we provide a discussion on the potential roles and implications of different sirtuins in skin-specific cellular processes, which may have relevance to skin health and skin diseases. Based on the available literature, the sirtuins appear to be important targets in the management of a variety of skin diseases from cosmetic (e.g., skin aging) to fatal conditions (e.g., melanoma).
  • |Animals [MESH]
  • |Humans [MESH]
  • |Oxidative Stress [MESH]
  • |Sirtuins/*metabolism [MESH]
  • |Skin Aging/physiology [MESH]
  • |Skin Neoplasms/*metabolism [MESH]
  • |Ultraviolet Rays [MESH]


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