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10.4155/fmc.14.44 http://scihub22266oqcxt.onion/10.4155/fmc.14.44 C4384657!4384657 !24962284     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=24962284 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\24962284 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Future+Med+Chem 2014 ; 6 (8 ): 945-66 Nephropedia Template TP {{tp|p=24962284 |t=2014. Sirtuin inhibitors as anticancer agents |pdf=|usr=}}{{24962284 }} gab.com Text Sirtuin inhibitors as anticancer agents JO: Future Med Chem http://www.kidney.de/pget.php?&tw=1&pmid=24962284 #FOAvip Sirtuins are a class of enzymes with nicotinamide adenine dinucleotide (NAD)-dependent protein lysine deacylase function. By deacylating various substrate proteins, including histones, transcription factors, and metabolic enzymes, sirtuins regulate various biological processes, such as transcription, cell survival, DNA damage and repair, and longevity. Small molecules that can inhibit sirtuins have been developed and many of them have shown anticancer activity. Here, we summarize the major biological findings that connect sirtuins to cancer and the different types of sirtuin inhibitors developed. Interestingly, biological data suggest that sirtuins have both tumor-suppressing and tumor-promoting roles. However, most pharmacological studies with small-molecule inhibitors suggest that inhibiting sirtuins has anticancer effects. We discuss possible explanations for this discrepancy and suggest possible future directions to further establish sirtuin inhibitors as anticancer agents. Twit Text FOAVip Sirtuin inhibitors as anticancer agents ????Future Med Chem http://www.kidney.de/pget.php?&tw=1&pmid=24962284 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24962284 #FOAvip English Wikipedia <ref>{{Cite pmid|24962284 }}</ref> Sirtuin inhibitors as anticancer agents #MMPMID24962284 Hu J ; Jing H ; Lin H Future Med Chem 2014[May]; 6 (8 ): 945-66 PMID24962284 show ga Sirtuins are a class of enzymes with nicotinamide adenine dinucleotide (NAD)-dependent protein lysine deacylase function. By deacylating various substrate proteins, including histones, transcription factors, and metabolic enzymes, sirtuins regulate various biological processes, such as transcription, cell survival, DNA damage and repair, and longevity. Small molecules that can inhibit sirtuins have been developed and many of them have shown anticancer activity. Here, we summarize the major biological findings that connect sirtuins to cancer and the different types of sirtuin inhibitors developed. Interestingly, biological data suggest that sirtuins have both tumor-suppressing and tumor-promoting roles. However, most pharmacological studies with small-molecule inhibitors suggest that inhibiting sirtuins has anticancer effects. We discuss possible explanations for this discrepancy and suggest possible future directions to further establish sirtuin inhibitors as anticancer agents. |Animals [MESH] |Antineoplastic Agents/*chemistry/metabolism/therapeutic use [MESH] |Benzamides/chemistry/metabolism/therapeutic use [MESH] |Enzyme Inhibitors/*chemistry/metabolism/therapeutic use [MESH] |Humans [MESH] |Naphthols/chemistry/metabolism/therapeutic use [MESH] |Neoplasms/drug therapy/metabolism/pathology [MESH] |Niacinamide/analogs & derivatives/metabolism/therapeutic use [MESH] |Protein Binding [MESH] |Reactive Oxygen Species/metabolism [MESH]Sirtuin inhibitors as anticancer agents (epmc).pdf DeepDyve Pubget Overpricing