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10.1016/B978-0-12-394624-9.00002-6

http://scihub22266oqcxt.onion/10.1016/B978-0-12-394624-9.00002-6
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suck abstract from ncbi


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pmid25081613
      Prog+Mol+Biol+Transl+Sci 2014 ; 126 (ä): 25-51
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  • Single-cell imaging of mechanotransduction in endothelial cells #MMPMID25081613
  • Lu S ; Wang Y
  • Prog Mol Biol Transl Sci 2014[]; 126 (ä): 25-51 PMID25081613 show ga
  • Endothelial cells (ECs) are constantly exposed to chemical and mechanical microenvironment in vivo. In mechanotransduction, cells can sense and translate the extracellular mechanical cues into intracellular biochemical signals, to regulate cellular processes. This regulation is crucial for many physiological functions, such as cell adhesion, migration, proliferation, and survival, as well as the progression of disease such as atherosclerosis. Here, we overview the current molecular understanding of mechanotransduction in ECs associated with atherosclerosis, especially those in response to physiological shear stress. The enabling technology of live-cell imaging has allowed the study of spatiotemporal molecular events and unprecedented understanding of intracellular signaling responses in mechanotransduction. Hence, we also introduce recent studies on mechanotransduction using single-cell imaging technologies.
  • |*Mechanotransduction, Cellular [MESH]
  • |Animals [MESH]
  • |Endothelial Cells/*metabolism [MESH]
  • |Focal Adhesions/metabolism [MESH]
  • |Humans [MESH]
  • |Molecular Imaging/*methods [MESH]
  • |Single-Cell Analysis/*methods [MESH]


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