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2014 ; 126
(ä): 25-51
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Single-cell imaging of mechanotransduction in endothelial cells
#MMPMID25081613
Lu S
; Wang Y
Prog Mol Biol Transl Sci
2014[]; 126
(ä): 25-51
PMID25081613
show ga
Endothelial cells (ECs) are constantly exposed to chemical and mechanical
microenvironment in vivo. In mechanotransduction, cells can sense and translate
the extracellular mechanical cues into intracellular biochemical signals, to
regulate cellular processes. This regulation is crucial for many physiological
functions, such as cell adhesion, migration, proliferation, and survival, as well
as the progression of disease such as atherosclerosis. Here, we overview the
current molecular understanding of mechanotransduction in ECs associated with
atherosclerosis, especially those in response to physiological shear stress. The
enabling technology of live-cell imaging has allowed the study of spatiotemporal
molecular events and unprecedented understanding of intracellular signaling
responses in mechanotransduction. Hence, we also introduce recent studies on
mechanotransduction using single-cell imaging technologies.