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10.1016/j.dnarep.2014.02.003 http://scihub22266oqcxt.onion/10.1016/j.dnarep.2014.02.003 C5125534!5125534 !24819596     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=24819596 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\24819596 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       DNA+Repair+(Amst) 2014 ; 20 (ä): 2-13 Nephropedia Template TP {{tp|p=24819596 |t=2014. Single molecule techniques in DNA repair: a primer |pdf=|usr=}}{{24819596 }} gab.com Text Single molecule techniques in DNA repair: a primer JO: DNA Repair (Amst) http://www.kidney.de/pget.php?&tw=1&pmid=24819596 #FOAvip A powerful new approach has become much more widespread and offers insights into aspects of DNA repair unattainable with billions of molecules. Single molecule techniques can be used to image, manipulate or characterize the action of a single repair protein on a single strand of DNA. This allows search mechanisms to be probed, and the effects of force to be understood. These physical aspects can dominate a biochemical reaction, where at the ensemble level their nuances are obscured. In this paper we discuss some of the many technical advances that permit study at the single molecule level. We focus on DNA repair to which these techniques are actively being applied. DNA repair is also a process that encompasses so much of what single molecule studies benefit--searching for targets, complex formation, sequential biochemical reactions and substrate hand-off to name just a few. We discuss how single molecule biophysics is poised to transform our understanding of biological systems, in particular DNA repair. Twit Text FOAVip Single molecule techniques in DNA repair: a primer ????DNA Repair (Amst) http://www.kidney.de/pget.php?&tw=1&pmid=24819596 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24819596 #FOAvip English Wikipedia <ref>{{Cite pmid|24819596 }}</ref> Single molecule techniques in DNA repair: a primer #MMPMID24819596 Hughes CD ; Simons M ; Mackenzie CE ; Van Houten B ; Kad NM DNA Repair (Amst) 2014[Aug]; 20 (ä): 2-13 PMID24819596 show ga A powerful new approach has become much more widespread and offers insights into aspects of DNA repair unattainable with billions of molecules. Single molecule techniques can be used to image, manipulate or characterize the action of a single repair protein on a single strand of DNA. This allows search mechanisms to be probed, and the effects of force to be understood. These physical aspects can dominate a biochemical reaction, where at the ensemble level their nuances are obscured. In this paper we discuss some of the many technical advances that permit study at the single molecule level. We focus on DNA repair to which these techniques are actively being applied. DNA repair is also a process that encompasses so much of what single molecule studies benefit--searching for targets, complex formation, sequential biochemical reactions and substrate hand-off to name just a few. We discuss how single molecule biophysics is poised to transform our understanding of biological systems, in particular DNA repair. |*DNA Repair [MESH] |*Optical Tweezers [MESH] |Animals [MESH] |Fluorescence Resonance Energy Transfer/*methods [MESH] |Humans [MESH] |Microscopy, Atomic Force/*methods [MESH]Single molecule techniques in DNA repair: a primer (epmc).pdf DeepDyve Pubget Overpricing