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Single cell sequencing: a distinct new field
#MMPMID28220395
Wang J
; Song Y
Clin Transl Med
2017[Dec]; 6
(1
): 10
PMID28220395
show ga
Single cell sequencing (SCS) has become a new approach to study biological
heterogeneity. The advancement in technologies for single cell isolation,
amplification of genome/transcriptome and next-generation sequencing enables SCS
to reveal the inherent properties of a single cell from the large scale of the
genome, transcriptome or epigenome at high resolution. Recently, SCS has been
widely applied in various clinical and research fields, such as cancer biology
and oncology, immunology, microbiology, neurobiology and prenatal diagnosis. In
this review, we will discuss the development of SCS methods and focus on the
latest clinical and research applications of SCS.