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10.1007/s12199-014-0403-9 http://scihub22266oqcxt.onion/10.1007/s12199-014-0403-9 C4166593!4166593 !25135741     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=25135741 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25135741 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Environ+Health+Prev+Med 2014 ; 19 (5 ): 322-9 Nephropedia Template TP {{tp|p=25135741 |t=2014. Silica exposure and altered regulation of autoimmunity |pdf=|usr=}}{{25135741 }} gab.com Text Silica exposure and altered regulation of autoimmunity JO: Environ Health Prev Med http://www.kidney.de/pget.php?&tw=1&pmid=25135741 #FOAvip Silica particles and asbestos fibers, which are known as typical causatives of pneumoconiosis, induce lung fibrosis. Moreover, silicosis patients often complicate with autoimmune diseases, and asbestos-exposed patients suffer from malignant diseases such as pleural mesothelioma and lung cancer. We have been conducting experimental studies to investigate altered regulation of self-tolerance caused by silica exposure, including analyses using specimens such as plasma and immunocompetent cells obtained from silicosis patients, as a means of examining the supposition that silica exposure induces molecular and cellular biological alterations of immune cells. These approaches have resulted in the detection of several specific autoantibodies, alterations of CD95/Fas and its related molecules, and evidence of chronic activation of responder T cells and regulatory T cells following silica exposure. In this review, we present details of our investigations as an introduction to scientific approaches examining the immunological effects of environmental and occupational substances. Twit Text FOAVip Silica exposure and altered regulation of autoimmunity ????Environ Health Prev Med http://www.kidney.de/pget.php?&tw=1&pmid=25135741 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25135741 #FOAvip English Wikipedia <ref>{{Cite pmid|25135741 }}</ref> Silica exposure and altered regulation of autoimmunity #MMPMID25135741 Lee S ; Matsuzaki H ; Kumagai-Takei N ; Yoshitome K ; Maeda M ; Chen Y ; Kusaka M ; Urakami K ; Hayashi H ; Fujimoto W ; Nishimura Y ; Otsuki T Environ Health Prev Med 2014[Sep]; 19 (5 ): 322-9 PMID25135741 show ga Silica particles and asbestos fibers, which are known as typical causatives of pneumoconiosis, induce lung fibrosis. Moreover, silicosis patients often complicate with autoimmune diseases, and asbestos-exposed patients suffer from malignant diseases such as pleural mesothelioma and lung cancer. We have been conducting experimental studies to investigate altered regulation of self-tolerance caused by silica exposure, including analyses using specimens such as plasma and immunocompetent cells obtained from silicosis patients, as a means of examining the supposition that silica exposure induces molecular and cellular biological alterations of immune cells. These approaches have resulted in the detection of several specific autoantibodies, alterations of CD95/Fas and its related molecules, and evidence of chronic activation of responder T cells and regulatory T cells following silica exposure. In this review, we present details of our investigations as an introduction to scientific approaches examining the immunological effects of environmental and occupational substances. |*Construction Industry [MESH] |*Occupational Exposure [MESH] |Autoimmunity/*drug effects [MESH] |Humans [MESH] |Japan [MESH] |Lymphocytes/drug effects/immunology [MESH] |Silicon Dioxide/*toxicity [MESH]Silica exposure and altered regulation of autoimmunity (epmc).pdf DeepDyve Pubget Overpricing