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2016 ; 129
(9
): 1751-8
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Signatures of breast cancer metastasis at a glance
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Karagiannis GS
; Goswami S
; Jones JG
; Oktay MH
; Condeelis JS
J Cell Sci
2016[May]; 129
(9
): 1751-8
PMID27084578
show ga
Gene expression profiling has yielded expression signatures from which prognostic
tests can be derived to facilitate clinical decision making in breast cancer
patients. Some of these signatures are based on profiling of whole tumor tissue
(tissue signatures), which includes all tumor and stromal cells. Prognostic
markers have also been derived from the profiling of metastasizing tumor cells,
including circulating tumor cells (CTCs) and migratory-disseminating tumor cells
within the primary tumor. The metastasis signatures based on CTCs and
migratory-disseminating tumor cells have greater potential for unraveling cell
biology insights and mechanistic underpinnings of tumor cell dissemination and
metastasis. Of clinical interest is the promise that stratification of patients
into high or low metastatic risk, as well as assessing the need for cytotoxic
therapy, might be improved if prognostics derived from these two types of
signatures are used in a combined way. The aim of this Cell Science at a Glance
article and accompanying poster is to navigate through both types of signatures
and their derived prognostics, as well as to highlight biological insights and
clinical applications that could be derived from them, especially when they are
used in combination.
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