Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\22012871
.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Wiley+Interdiscip+Rev+RNA
2012 ; 3
(3
): 385-96
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Signals for pre-mRNA cleavage and polyadenylation
#MMPMID22012871
Tian B
; Graber JH
Wiley Interdiscip Rev RNA
2012[May]; 3
(3
): 385-96
PMID22012871
show ga
Pre-mRNA cleavage and polyadenylation is an essential step for 3' end formation
of almost all protein-coding transcripts in eukaryotes. The reaction, involving
cleavage of nascent mRNA followed by addition of a polyadenylate or poly(A) tail,
is controlled by cis-acting elements in the pre-mRNA surrounding the cleavage
site. Experimental and bioinformatic studies in the past three decades have
elucidated conserved and divergent elements across eukaryotes, from yeast to
human. Here we review histories and current models of these elements in a broad
range of species.