Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26517881
.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Biochem+Soc+Trans
2015 ; 43
(5
): 763-72
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Signalling to eIF4E in cancer
#MMPMID26517881
Siddiqui N
; Sonenberg N
Biochem Soc Trans
2015[Oct]; 43
(5
): 763-72
PMID26517881
show ga
Translational control plays a critical role in the regulation of gene expression
in eukaryotes and affects many essential cellular processes, including
proliferation, apoptosis and differentiation. Under most circumstances,
translational control occurs at the initiation step at which the ribosome is
recruited to the mRNA. The eukaryotic translation initiation factor 4E (eIF4E),
as part of the eIF4F complex, interacts first with the mRNA and facilitates the
recruitment of the 40S ribosomal subunit. The activity of eIF4E is regulated at
many levels, most profoundly by two major signalling pathways: PI3K
(phosphoinositide 3-kinase)/Akt (also known and Protein Kinase B, PKB)/mTOR
(mechanistic/mammalian target of rapamycin) and Ras (rat sarcoma)/MAPK
(mitogen-activated protein kinase)/Mnk (MAPK-interacting kinases). mTOR directly
phosphorylates the 4E-BPs (eIF4E-binding proteins), which are inhibitors of
eIF4E, to relieve translational suppression, whereas Mnk phosphorylates eIF4E to
stimulate translation. Hyperactivation of these pathways occurs in the majority
of cancers, which results in increased eIF4E activity. Thus, translational
control via eIF4E acts as a convergence point for hyperactive signalling pathways
to promote tumorigenesis. Consequently, recent works have aimed to target these
pathways and ultimately the translational machinery for cancer therapy.
free
free
free
