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10.1038/s41467-017-00573-w http://scihub22266oqcxt.onion/10.1038/s41467-017-00573-w C5585373!5585373 !28874664     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28874664 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28874664 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Nat+Commun 2017 ; 8 (1 ): 427 Nephropedia Template TP {{tp|p=28874664 |t=2017. Signalling strength determines proapoptotic functions of STING |pdf=|usr=}}{{28874664 }} gab.com Text Signalling strength determines proapoptotic functions of STING JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=28874664 #FOAvip Mammalian cells use cytosolic nucleic acid receptors to detect pathogens and other stress signals. In innate immune cells the presence of cytosolic DNA is sensed by the cGAS-STING signalling pathway, which initiates a gene expression programme linked to cellular activation and cytokine production. Whether the outcome of the STING response varies between distinct cell types remains largely unknown. Here we show that T cells exhibit an intensified STING response, which leads to the expression of a distinct set of genes and results in the induction of apoptosis. Of note, this proapoptotic STING response is still functional in cancerous T cells and delivery of small molecule STING agonists prevents in vivo growth of T-cell-derived tumours independent of its adjuvant activity. Our results demonstrate how the magnitude of STING signalling can shape distinct effector responses, which may permit for cell type-adjusted behaviours towards endogenous or exogenous insults.The cGAS/STING signalling pathway is responsible for sensing intracellular DNA and activating downstream inflammatory genes. Here the authors show mouse primary T cells and T leukaemia are hyperresponsive to STING agonist, and this strong STING signalling is associated with apoptosis induction. Twit Text FOAVip Signalling strength determines proapoptotic functions of STING ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=28874664 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28874664 #FOAvip English Wikipedia <ref>{{Cite pmid|28874664 }}</ref> Signalling strength determines proapoptotic functions of STING #MMPMID28874664 Gulen MF ; Koch U ; Haag SM ; Schuler F ; Apetoh L ; Villunger A ; Radtke F ; Ablasser A Nat Commun 2017[Sep]; 8 (1 ): 427 PMID28874664 show ga Mammalian cells use cytosolic nucleic acid receptors to detect pathogens and other stress signals. In innate immune cells the presence of cytosolic DNA is sensed by the cGAS-STING signalling pathway, which initiates a gene expression programme linked to cellular activation and cytokine production. Whether the outcome of the STING response varies between distinct cell types remains largely unknown. Here we show that T cells exhibit an intensified STING response, which leads to the expression of a distinct set of genes and results in the induction of apoptosis. Of note, this proapoptotic STING response is still functional in cancerous T cells and delivery of small molecule STING agonists prevents in vivo growth of T-cell-derived tumours independent of its adjuvant activity. Our results demonstrate how the magnitude of STING signalling can shape distinct effector responses, which may permit for cell type-adjusted behaviours towards endogenous or exogenous insults.The cGAS/STING signalling pathway is responsible for sensing intracellular DNA and activating downstream inflammatory genes. Here the authors show mouse primary T cells and T leukaemia are hyperresponsive to STING agonist, and this strong STING signalling is associated with apoptosis induction. |*Apoptosis [MESH] |*Signal Transduction [MESH] |Animals [MESH] |Interferon Regulatory Factor-3/metabolism [MESH] |Leukemia, T-Cell/immunology/pathology [MESH] |Membrane Proteins/*metabolism [MESH] |Mice, Inbred C57BL [MESH] |Protein Binding [MESH] |T-Lymphocytes/metabolism [MESH] |Transcription, Genetic [MESH]Signalling strength determines proapoptotic functions of STING (epmc).pdf DeepDyve Pubget Overpricing