10.1002/dvdy.24472 http://scihub22266oqcxt.onion/10.1002/dvdy.24472 C5354978!5354978
!27859991
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Dev+Dyn
2017 ; 246
(4
): 262-274
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Signaling networks in joint development
#MMPMID27859991
Salva JE
; Merrill AE
Dev Dyn
2017[Apr]; 246
(4
): 262-274
PMID27859991
show ga
Here we review studies identifying regulatory networks responsible for synovial,
cartilaginous, and fibrous joint development. Synovial joints, characterized by
the fluid-filled synovial space between the bones, are found in high-mobility
regions and are the most common type of joint. Cartilaginous joints such as the
intervertebral disc unite adjacent bones through either a hyaline cartilage or a
fibrocartilage intermediate. Fibrous joints, which include the cranial sutures,
form a direct union between bones through fibrous connective tissue. We describe
how the distinct morphologic and histogenic characteristics of these joint
classes are established during embryonic development. Collectively, these studies
reveal that despite the heterogeneity of joint strength and mobility, joint
development throughout the skeleton utilizes common signaling networks via
long-range morphogen gradients and direct cell-cell contact. This suggests that
different joint types represent specialized variants of homologous developmental
modules. Identifying the unifying aspects of the signaling networks between joint
classes allows a more complete understanding of the signaling code for joint
formation, which is critical to improving strategies for joint regeneration and
repair. Developmental Dynamics 246:262-274, 2017. © 2016 Wiley Periodicals, Inc.
Please enable JavaScript to view the comments powered by Disqus. |Animals
[MESH] |Cartilage, Articular
[MESH] |Gene Regulatory Networks
[MESH] |Humans
[MESH] |Joint Capsule
[MESH] |Joints/anatomy & histology/embryology/*growth & development
[MESH] |Morphogenesis
[MESH] |Regeneration
[MESH] DeepDyve Pubget Overpricing