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2014 ; 32
(7
): 356-62
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Signaling hypergraphs
#MMPMID24857424
Ritz A
; Tegge AN
; Kim H
; Poirel CL
; Murali TM
Trends Biotechnol
2014[Jul]; 32
(7
): 356-62
PMID24857424
show ga
Signaling pathways function as the information-passing mechanisms of cells. A
number of databases with extensive manual curation represent the current
knowledge base for signaling pathways. These databases motivate the development
of computational approaches for prediction and analysis. Such methods require an
accurate and computable representation of signaling pathways. Pathways are often
described as sets of proteins or as pairwise interactions between proteins.
However, many signaling mechanisms cannot be described using these
representations. In this opinion, we highlight a representation of signaling
pathways that is underutilized: the hypergraph. We demonstrate the usefulness of
hypergraphs in this context and discuss challenges and opportunities for the
scientific community.