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Signaling during Kidney Development
#MMPMID25867084
Krause M
; Rak-Raszewska A
; Pietilä I
; Quaggin SE
; Vainio S
Cells
2015[Apr]; 4
(2
): 112-32
PMID25867084
show ga
The kidney plays an essential role during excretion of metabolic waste products,
maintenance of key homeostasis components such as ion concentrations and hormone
levels. It influences the blood pressure, composition and volume. The kidney
tubule system is composed of two distinct cell populations: the nephrons forming
the filtering units and the collecting duct system derived from the ureteric bud.
Nephrons are composed of glomeruli that filter the blood to the Bowman's capsule
and tubular structures that reabsorb and concentrate primary urine. The
collecting duct is a Wolffian duct-derived epithelial tube that concentrates and
collects urine and transfers it via the renal pelvis into the bladder. The
mammalian kidney function depends on the coordinated development of specific cell
types within a precise architectural framework. Due to the availability of modern
analysis techniques, the kidney has become a model organ defining the paradigm to
study organogenesis. As kidney diseases are a problem worldwide, the
understanding of mammalian kidney cells is of crucial importance to develop
diagnostic tools and novel therapies. This review focuses on how the pattern of
renal development is generated, how the inductive signals are regulated and what
are their effects on proliferation, differentiation and morphogenesis.
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