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2017 ; 35
(ä): 285-311
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Signaling by Antibodies: Recent Progress
#MMPMID28446061
Bournazos S
; Wang TT
; Dahan R
; Maamary J
; Ravetch JV
Annu Rev Immunol
2017[Apr]; 35
(ä): 285-311
PMID28446061
show ga
IgG antibodies mediate a diversity of immune functions by coupling of antigen
specificity through the Fab domain to signal transduction via Fc-Fc receptor
interactions. Indeed, balanced IgG signaling through type I and type II Fc
receptors is required for the control of proinflammatory, anti-inflammatory, and
immunomodulatory processes. In this review, we discuss the mechanisms that govern
IgG-Fc receptor interactions, highlighting the diversity of Fc receptor-mediated
effector functions that regulate immunity and inflammation as well as determine
susceptibility to infection and autoimmunity and responsiveness to antibody-based
therapeutics and vaccines.