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10.1146/annurev-immunol-051116-052433

http://scihub22266oqcxt.onion/10.1146/annurev-immunol-051116-052433
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suck abstract from ncbi


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pmid28446061
      Annu+Rev+Immunol 2017 ; 35 (ä): 285-311
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  • Signaling by Antibodies: Recent Progress #MMPMID28446061
  • Bournazos S ; Wang TT ; Dahan R ; Maamary J ; Ravetch JV
  • Annu Rev Immunol 2017[Apr]; 35 (ä): 285-311 PMID28446061 show ga
  • IgG antibodies mediate a diversity of immune functions by coupling of antigen specificity through the Fab domain to signal transduction via Fc-Fc receptor interactions. Indeed, balanced IgG signaling through type I and type II Fc receptors is required for the control of proinflammatory, anti-inflammatory, and immunomodulatory processes. In this review, we discuss the mechanisms that govern IgG-Fc receptor interactions, highlighting the diversity of Fc receptor-mediated effector functions that regulate immunity and inflammation as well as determine susceptibility to infection and autoimmunity and responsiveness to antibody-based therapeutics and vaccines.
  • |Animals [MESH]
  • |Antibodies/*therapeutic use [MESH]
  • |Autoimmune Diseases/*immunology/therapy [MESH]
  • |Disease Susceptibility [MESH]
  • |Humans [MESH]
  • |Immunity, Humoral [MESH]
  • |Immunoglobulin G/*metabolism [MESH]
  • |Immunotherapy/*methods [MESH]
  • |Infections/*immunology/therapy [MESH]
  • |Inflammation [MESH]
  • |Receptors, Fc/*metabolism [MESH]


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