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2018 ; 38
(3
): ä Nephropedia Template TP
gab.com Text
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English Wikipedia
Shooting the messenger: RNA-targetting CRISPR-Cas systems
#MMPMID29748239
Zhu Y
; Klompe SE
; Vlot M
; van der Oost J
; Staals RHJ
Biosci Rep
2018[Jun]; 38
(3
): ä PMID29748239
show ga
Since the discovery of CRISPR-Cas (Clustered Regularly Interspaced Short
Palindromic Repeats, CRISPR-associated genes) immune systems, astonishing
progress has been made on revealing their mechanistic foundations. Due to the
immense potential as genome engineering tools, research has mainly focussed on a
subset of Cas nucleases that target DNA. In addition, however, distinct types of
RNA-targetting CRISPR-Cas systems have been identified. The focus of this review
will be on the interference mechanisms of the RNA targetting type III and type VI
CRISPR-Cas systems, their biological relevance and their potential for
applications.
|*CRISPR-Cas Systems
[MESH]
|*Clustered Regularly Interspaced Short Palindromic Repeats
[MESH]
|*Genome
[MESH]
|Adaptive Immunity
[MESH]
|Animals
[MESH]
|Bacteria/*genetics/immunology
[MESH]
|Bacteriophages/genetics/metabolism
[MESH]
|CRISPR-Associated Protein 9/*genetics/metabolism
[MESH]