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10.1042/BSR20170788

http://scihub22266oqcxt.onion/10.1042/BSR20170788
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C6013697!6013697 !29748239
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suck abstract from ncbi


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pmid29748239
      Biosci+Rep 2018 ; 38 (3 ): ä
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  • Shooting the messenger: RNA-targetting CRISPR-Cas systems #MMPMID29748239
  • Zhu Y ; Klompe SE ; Vlot M ; van der Oost J ; Staals RHJ
  • Biosci Rep 2018[Jun]; 38 (3 ): ä PMID29748239 show ga
  • Since the discovery of CRISPR-Cas (Clustered Regularly Interspaced Short Palindromic Repeats, CRISPR-associated genes) immune systems, astonishing progress has been made on revealing their mechanistic foundations. Due to the immense potential as genome engineering tools, research has mainly focussed on a subset of Cas nucleases that target DNA. In addition, however, distinct types of RNA-targetting CRISPR-Cas systems have been identified. The focus of this review will be on the interference mechanisms of the RNA targetting type III and type VI CRISPR-Cas systems, their biological relevance and their potential for applications.
  • |*CRISPR-Cas Systems [MESH]
  • |*Clustered Regularly Interspaced Short Palindromic Repeats [MESH]
  • |*Genome [MESH]
  • |Adaptive Immunity [MESH]
  • |Animals [MESH]
  • |Bacteria/*genetics/immunology [MESH]
  • |Bacteriophages/genetics/metabolism [MESH]
  • |CRISPR-Associated Protein 9/*genetics/metabolism [MESH]
  • |DNA Transposable Elements [MESH]
  • |DNA/*genetics/metabolism [MESH]
  • |Gene Editing/*methods [MESH]
  • |Humans [MESH]
  • |Plasmids/chemistry/metabolism [MESH]


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