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10.1097/MOH.0000000000000070 http://scihub22266oqcxt.onion/10.1097/MOH.0000000000000070 C4175399!4175399 !25023471     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=25023471 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25023471 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Curr+Opin+Hematol 2014 ; 21 (5 ): 410-7 Nephropedia Template TP {{tp|p=25023471 |t=2014. Shaping the platelet response to vascular injury |pdf=|usr=}}{{25023471 }} gab.com Text Shaping the platelet response to vascular injury JO: Curr Opin Hematol http://www.kidney.de/pget.php?&tw=1&pmid=25023471 #FOAvip PURPOSE OF REVIEW: Several decades of work by many investigators have elucidated the major signaling pathways responsible for platelet activation. Still to be fully understood is how these pathways are integrated into a single network and how changing conditions within a growing thrombus affect that network. In this review we will consider some of the recent studies that address these issues and describe a model that provides insights into platelet activation as it occurs in vivo. RECENT FINDINGS: Genetic and pharmacologic studies performed in vivo have demonstrated that platelet activation during hemostasis and thrombosis is heterogeneous. Those studies indicate that distinct platelet activation pathways are not merely redundant, but are coordinated in time and space to achieve an optimal response. This coordination is achieved at least in part by the evolving distribution of platelet agonists and changes in solute transport within a hemostatic plug. SUMMARY: Studies examining the coordination of platelet signaling in time and space continue to increase our understanding of hemostasis and thrombosis. In addition to helping to decipher platelet biology, the results have implications for the understanding of new and existing antiplatelet agents and their potential risks. Twit Text FOAVip Shaping the platelet response to vascular injury ????Curr Opin Hematol http://www.kidney.de/pget.php?&tw=1&pmid=25023471 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25023471 #FOAvip English Wikipedia <ref>{{Cite pmid|25023471 }}</ref> Shaping the platelet response to vascular injury #MMPMID25023471 Stalker TJ ; Welsh JD ; Brass LF Curr Opin Hematol 2014[Sep]; 21 (5 ): 410-7 PMID25023471 show ga PURPOSE OF REVIEW: Several decades of work by many investigators have elucidated the major signaling pathways responsible for platelet activation. Still to be fully understood is how these pathways are integrated into a single network and how changing conditions within a growing thrombus affect that network. In this review we will consider some of the recent studies that address these issues and describe a model that provides insights into platelet activation as it occurs in vivo. RECENT FINDINGS: Genetic and pharmacologic studies performed in vivo have demonstrated that platelet activation during hemostasis and thrombosis is heterogeneous. Those studies indicate that distinct platelet activation pathways are not merely redundant, but are coordinated in time and space to achieve an optimal response. This coordination is achieved at least in part by the evolving distribution of platelet agonists and changes in solute transport within a hemostatic plug. SUMMARY: Studies examining the coordination of platelet signaling in time and space continue to increase our understanding of hemostasis and thrombosis. In addition to helping to decipher platelet biology, the results have implications for the understanding of new and existing antiplatelet agents and their potential risks. |Animals [MESH] |Blood Platelets/*cytology/metabolism [MESH] |Cell Shape [MESH] |Humans [MESH] |Platelet Activation [MESH] |Signal Transduction [MESH]Shaping the platelet response to vascular injury (epmc).pdf DeepDyve Pubget Overpricing