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10.1038/npp.2014.319 http://scihub22266oqcxt.onion/10.1038/npp.2014.319 C4397394!4397394 !25469681     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=25469681 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25469681 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Neuropsychopharmacology 2015 ; 40 (6 ): 1364-72 Nephropedia Template TP {{tp|p=25469681 |t=2015. Sex-specific mechanism of social hierarchy in mice |pdf=|usr=}}{{25469681 }} gab.com Text Sex-specific mechanism of social hierarchy in mice JO: Neuropsychopharmacology http://www.kidney.de/pget.php?&tw=1&pmid=25469681 #FOAvip The establishment of social hierarchies is a naturally occurring, evolutionarily conserved phenomenon with a well-established impact on fitness and health. Investigations of complex social group dynamics may offer novel opportunities for translational studies of autism spectrum disorder. Here we describe a robust behavioral paradigm using an automated version of the tube test. Isogenic groups of male and female mice establish linear social hierarchies that remain highly stable for at least 14 days, the longest interval tested. Remarkably, however, their social strategy is sex-specific: females primarily utilize intrinsic attributes, whereas males are strongly influenced by prior social experience. Using both genetic and pharmacological manipulations, we identify testosterone as a critical sex-specific factor for determining which social strategy is used. Males inheriting a null mutation of the sex-determining region Y (Sry) gene used a similar social cognitive strategy as females. In contrast, females with transgenic expression of Sry utilized a typically male social strategy. Analogously, castration of males and testosterone supplementation of females yielded similar outcomes, with a reversal of their social cognitive strategy. Together, our results demonstrate a sex-specific mechanism underlying social hierarchy, in which both males and females retain the functional capacity to adapt their social strategy. More generally, we expect the automated tube test to provide an important complementary approach for both fundamental and translational studies of social behavior. Twit Text FOAVip Sex-specific mechanism of social hierarchy in mice ????Neuropsychopharmacology http://www.kidney.de/pget.php?&tw=1&pmid=25469681 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25469681 #FOAvip English Wikipedia <ref>{{Cite pmid|25469681 }}</ref> Sex-specific mechanism of social hierarchy in mice #MMPMID25469681 van den Berg WE ; Lamballais S ; Kushner SA Neuropsychopharmacology 2015[May]; 40 (6 ): 1364-72 PMID25469681 show ga The establishment of social hierarchies is a naturally occurring, evolutionarily conserved phenomenon with a well-established impact on fitness and health. Investigations of complex social group dynamics may offer novel opportunities for translational studies of autism spectrum disorder. Here we describe a robust behavioral paradigm using an automated version of the tube test. Isogenic groups of male and female mice establish linear social hierarchies that remain highly stable for at least 14 days, the longest interval tested. Remarkably, however, their social strategy is sex-specific: females primarily utilize intrinsic attributes, whereas males are strongly influenced by prior social experience. Using both genetic and pharmacological manipulations, we identify testosterone as a critical sex-specific factor for determining which social strategy is used. Males inheriting a null mutation of the sex-determining region Y (Sry) gene used a similar social cognitive strategy as females. In contrast, females with transgenic expression of Sry utilized a typically male social strategy. Analogously, castration of males and testosterone supplementation of females yielded similar outcomes, with a reversal of their social cognitive strategy. Together, our results demonstrate a sex-specific mechanism underlying social hierarchy, in which both males and females retain the functional capacity to adapt their social strategy. More generally, we expect the automated tube test to provide an important complementary approach for both fundamental and translational studies of social behavior. |*Genes, sry [MESH] |*Hierarchy, Social [MESH] |*Sex Characteristics [MESH] |*Social Behavior [MESH] |Animals [MESH] |Castration [MESH] |Female [MESH] |Learning/physiology [MESH] |Male [MESH] |Mice/*physiology/*psychology [MESH] |Mutation [MESH] |Psychological Tests [MESH]Sex-specific mechanism of social hierarchy in mice (epmc).pdf DeepDyve Pubget Overpricing