Sex and the single transplanted kidney
#MMPMID27088804
Noel S
; Desai NM
; Hamad AR
; Rabb H
J Clin Invest
2016[May]; 126
(5
): 1643-5
PMID27088804
show ga
Substantial ischemia-reperfusion injury (IRI) to the transplanted kidney occurs
in 30% to 50% of transplantation patients who receive the organ from a deceased
donor. IRI usually manifests as delayed graft function (DGF) and, in severe
cases, results in primary nonfunction. Previous studies, primarily experimental,
have demonstrated sex-specific susceptibility to IRI in kidney and other organs.
In this issue of the JCI, Aufhauser Jr., Wang, and colleagues further demonstrate
the importance of donor and recipient sex in IRI and elucidate the role of
estrogen receptors in a murine model. Furthermore, analysis of data from 46,691
renal transplant patients in the United Network for Organ Sharing (UNOS) database
revealed that sex affects DGF outcomes in humans. Manipulation of sex-driven
molecular pathways offers a fertile opportunity to increase the number of organs
available for transplantation and to reduce IRI in kidney and, likely, other
organs.
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