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10.1016/j.jaip.2014.06.022 http://scihub22266oqcxt.onion/10.1016/j.jaip.2014.06.022 C4589165!4589165 !25213041     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=25213041 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25213041 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       J+Allergy+Clin+Immunol+Pract 2014 ; 2 (5 ): 489-500 Nephropedia Template TP {{tp|p=25213041 |t=2014. Severe asthma in children |pdf=|usr=}}{{25213041 }} gab.com Text Severe asthma in children JO: J Allergy Clin Immunol Pract http://www.kidney.de/pget.php?&tw=1&pmid=25213041 #FOAvip Severe asthma in children is characterized by sustained symptoms despite treatment with high doses of inhaled corticosteroids or oral corticosteroids. Children with severe asthma may fall into 2 categories, difficult-to-treat asthma or severe therapy-resistant asthma. Difficult-to-treat asthma is defined as poor control due to an incorrect diagnosis or comorbidities, or poor adherence due to adverse psychological or environmental factors. In contrast, treatment resistant is defined as difficult asthma despite management of these factors. It is increasingly recognized that severe asthma is a highly heterogeneous disorder associated with a number of clinical and inflammatory phenotypes that have been described in children with severe asthma. Guideline-based drug therapy of severe childhood asthma is based primarily on extrapolated data from adult studies. The recommendation is that children with severe asthma be treated with higher-dose inhaled or oral corticosteroids combined with long-acting ?-agonists and other add-on therapies, such as antileukotrienes and methylxanthines. It is important to identify and address the influences that make asthma difficult to control, including reviewing the diagnosis and removing causal or aggravating factors. Better definition of the phenotypes and better targeting of therapy based upon individual patient phenotypes is likely to improve asthma treatment in the future. Twit Text FOAVip Severe asthma in children ????J Allergy Clin Immunol Pract http://www.kidney.de/pget.php?&tw=1&pmid=25213041 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25213041 #FOAvip English Wikipedia <ref>{{Cite pmid|25213041 }}</ref> Severe asthma in children #MMPMID25213041 Guilbert TW ; Bacharier LB ; Fitzpatrick AM J Allergy Clin Immunol Pract 2014[Sep]; 2 (5 ): 489-500 PMID25213041 show ga Severe asthma in children is characterized by sustained symptoms despite treatment with high doses of inhaled corticosteroids or oral corticosteroids. Children with severe asthma may fall into 2 categories, difficult-to-treat asthma or severe therapy-resistant asthma. Difficult-to-treat asthma is defined as poor control due to an incorrect diagnosis or comorbidities, or poor adherence due to adverse psychological or environmental factors. In contrast, treatment resistant is defined as difficult asthma despite management of these factors. It is increasingly recognized that severe asthma is a highly heterogeneous disorder associated with a number of clinical and inflammatory phenotypes that have been described in children with severe asthma. Guideline-based drug therapy of severe childhood asthma is based primarily on extrapolated data from adult studies. The recommendation is that children with severe asthma be treated with higher-dose inhaled or oral corticosteroids combined with long-acting ?-agonists and other add-on therapies, such as antileukotrienes and methylxanthines. It is important to identify and address the influences that make asthma difficult to control, including reviewing the diagnosis and removing causal or aggravating factors. Better definition of the phenotypes and better targeting of therapy based upon individual patient phenotypes is likely to improve asthma treatment in the future. |*Asthma/diagnosis/drug therapy/epidemiology/physiopathology [MESH] |Adolescent [MESH] |Adrenal Cortex Hormones/therapeutic use [MESH] |Adult [MESH] |Anti-Asthmatic Agents/therapeutic use [MESH] |Child [MESH] |Child, Preschool [MESH] |Diagnosis, Differential [MESH] |Humans [MESH] |Life Style [MESH] |Patient Education as Topic [MESH]Severe asthma in children (epmc).pdf DeepDyve Pubget Overpricing