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10.1016/j.bjid.2025.104573 http://scihub22266oqcxt.onion/10.1016/j.bjid.2025.104573 40784249!12357306!40784249     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=40784249&cmd=llinks): Failed to open stream: HTTP request failed! 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Severe Staphylococcus aureus infection: associated factors and outcomes |pdf=|usr=}}{{40784249}} gab.com Text Severe Staphylococcus aureus infection: associated factors and outcomes JO: Braz J Infect Dis http://www.kidney.de/pget.php?&tw=1&pmid=40784249 #FOAvip INTRODUCTION: Staphylococcus aureus causes potentially life-threatening infections, with a somber prognosis when the infection is caused by methicillin-resistant S. aureus due to limited treatment options. The present study describes serious infections by S. aureus in patients hospitalized in an infectious disease's unit in Rio de Janeiro, Brazil, between 2016 and 2021. MATERIAL AND METHODS: This was a retrospective study based on data from positive samples diagnosed by the microbiology laboratory and by review of medical records. Clinical-demographic variables and outcomes were compared between Patients Living with HIV (PLHIV) and non-HIV patients. Data were analyzed using Jamovi 1.6 and R 4.0.1 statistical software. RESULTS: A total of 67 patients with a serious S. aureus infection were identified, of whom 29 presented bacteremia and 38 other infections. Thirty-one of 67 (46.3%) were PLHIV. The median age of all patients was 46years, although PLHIV were significantly younger than non-HIV individuals (36 vs. 60 years-old, p < 0.001). The median CD4 lymphocyte count was 95 cells/mm(3). Community infection occurred in 36/67 (53.7%) patients, of whom 19/36 (52.7%) had bacteremia. A total of 20 MRSA infections (29.9% of the patients) were identified, which accounted for 14/36 (38.8%) of the community infections. More than a third of PLHIV (38.7%) had MRSA, and all these were sensitive to cotrimoxazole. No difference in mortality was found between PLHIV and non-HIV patients, nor between the MRSA and MSSA groups. Bacteremia was present in 29 patients; MRSA accounted for 9 (31.0%) of these. The 30-day mortality was 4/9 (44.4%) and 2/20 (10%) in MRSA and MSSA bacteremia, respectively. CONCLUSIONS: The most frequent comorbidity in patients with severe S. aureus infections was HIV, with a high rate of MRSA infections recorded in PLHIV. PLHIV were younger, but did not suffer higher mortality, although they did have more relapses and new staphylococcal infections. Twit Text FOAVip Severe Staphylococcus aureus infection: associated factors and outcomes ????Braz J Infect Dis http://www.kidney.de/pget.php?&tw=1&pmid=40784249 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=40784249 #FOAvip English Wikipedia <ref>{{Cite pmid|40784249}}</ref> Severe Staphylococcus aureus infection: associated factors and outcomes #MMPMID40784249 Valobdas NB; Alves MR; Silva EADSRD; Lourenco MCDS; Nascimento BCN; Veloso VG; Cardoso SW; Cardoso; Lamas CDC Braz J Infect Dis 2025[Aug]; 29 (5): 104573 PMID40784249show ga INTRODUCTION: Staphylococcus aureus causes potentially life-threatening infections, with a somber prognosis when the infection is caused by methicillin-resistant S. aureus due to limited treatment options. The present study describes serious infections by S. aureus in patients hospitalized in an infectious disease's unit in Rio de Janeiro, Brazil, between 2016 and 2021. MATERIAL AND METHODS: This was a retrospective study based on data from positive samples diagnosed by the microbiology laboratory and by review of medical records. Clinical-demographic variables and outcomes were compared between Patients Living with HIV (PLHIV) and non-HIV patients. Data were analyzed using Jamovi 1.6 and R 4.0.1 statistical software. RESULTS: A total of 67 patients with a serious S. aureus infection were identified, of whom 29 presented bacteremia and 38 other infections. Thirty-one of 67 (46.3%) were PLHIV. The median age of all patients was 46years, although PLHIV were significantly younger than non-HIV individuals (36 vs. 60 years-old, p < 0.001). The median CD4 lymphocyte count was 95 cells/mm(3). Community infection occurred in 36/67 (53.7%) patients, of whom 19/36 (52.7%) had bacteremia. A total of 20 MRSA infections (29.9% of the patients) were identified, which accounted for 14/36 (38.8%) of the community infections. More than a third of PLHIV (38.7%) had MRSA, and all these were sensitive to cotrimoxazole. No difference in mortality was found between PLHIV and non-HIV patients, nor between the MRSA and MSSA groups. Bacteremia was present in 29 patients; MRSA accounted for 9 (31.0%) of these. The 30-day mortality was 4/9 (44.4%) and 2/20 (10%) in MRSA and MSSA bacteremia, respectively. CONCLUSIONS: The most frequent comorbidity in patients with severe S. aureus infections was HIV, with a high rate of MRSA infections recorded in PLHIV. PLHIV were younger, but did not suffer higher mortality, although they did have more relapses and new staphylococcal infections. äSevere Staphylococcus aureus infection: associated factors and outcome(epmc).pdf DeepDyve Pubget Overpricing