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2015 ; 94
(2
): e387
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Serum IgG subclasses in autoimmune diseases
#MMPMID25590841
Zhang H
; Li P
; Wu D
; Xu D
; Hou Y
; Wang Q
; Li M
; Li Y
; Zeng X
; Zhang F
; Shi Q
Medicine (Baltimore)
2015[Jan]; 94
(2
): e387
PMID25590841
show ga
To characterize serum IgG subclass levels in several autoimmune diseases,
including primary Sjogren syndrome (pSS), systemic sclerosis (SSc), systemic
lupus erythematosus (SLE), and primary biliary cirrhosis (PBC). We aimed to
analyze serum IgG subclass distribution and to test whether serum IgG4 levels are
elevated in these diseases. Serum IgG subclass levels from 102 pSS, 102 SSc, 100
SLE, and 59 PBC patients, as well as 40 healthy controls (HCs), were measured
using the immunonephelometric assay. The distribution of IgG subclasses among
these autoimmune diseases was analyzed. In this cross-sectional study, serum IgG1
(IgG1/IgG) and/or IgG3 (IgG3/IgG) were significantly increased, compared with
those in HCs. Only 6.34% of patients had levels of serum IgG4 >135 mg/dL. There
were no significant differences in the frequency of elevated serum IgG4 levels
between patients and HC. In pSS, serum IgG1 levels were much higher than those in
other disease groups, whereas serum IgG2 and IgG3 levels were most prominently
increased in PBC. A strikingly different serum IgG subclass distribution was
detected in patients with autoimmune diseases compared with HCs. Serum IgG
subclass levels also showed distinct characteristics among different autoimmune
diseases. Serum IgG4 levels in these patients were lower or not much higher than
those in HCs, which differed from IgG4-related diseases.