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10.1016/j.semcdb.2014.02.011 http://scihub22266oqcxt.onion/10.1016/j.semcdb.2014.02.011 C4043859!4043859 !24603046     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\24603046 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Semin+Cell+Dev+Biol 2014 ; 30 (ä): 36-44 Nephropedia Template TP {{tp|p=24603046 |t=2014. Sertoli cells--immunological sentinels of spermatogenesis |pdf=|usr=}}{{24603046 }} gab.com Text Sertoli cells--immunological sentinels of spermatogenesis JO: Semin Cell Dev Biol http://www.kidney.de/pget.php?&tw=1&pmid=24603046 #FOAvip Testicular germ cells, which appear after the establishment of central tolerance, express novel cell surface and intracellular proteins that can be recognized as 'foreign antigens' by the host's immune system. However, normally these germ cells do not evoke an auto-reactive immune response. The focus of this manuscript is to review the evidence that the blood-testis-barrier (BTB)/Sertoli cell (SC) barrier along with the SCs ability to modulate the immune response is vital for protecting auto-antigenic germ cells. In normal testis, the BTB/SC barrier protects the majority of the auto-antigenic germ cells by limiting access by the immune system and sequestering these 'new antigens'. SCs also modulate testis immune cells (induce regulatory immune cells) by expressing several immunoregulatory factors, thereby creating a local tolerogenic environment optimal for survival of nonsequesetred auto-antigenic germ cells. Collectively, the fortress created by the BTB/SC barrier along with modulation of the immune response is pivotal for completion of spermatogenesis and species survival. Twit Text FOAVip Sertoli cells--immunological sentinels of spermatogenesis ????Semin Cell Dev Biol http://www.kidney.de/pget.php?&tw=1&pmid=24603046 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24603046 #FOAvip English Wikipedia <ref>{{Cite pmid|24603046 }}</ref> Sertoli cells--immunological sentinels of spermatogenesis #MMPMID24603046 Kaur G ; Thompson LA ; Dufour JM Semin Cell Dev Biol 2014[Jun]; 30 (ä): 36-44 PMID24603046 show ga Testicular germ cells, which appear after the establishment of central tolerance, express novel cell surface and intracellular proteins that can be recognized as 'foreign antigens' by the host's immune system. However, normally these germ cells do not evoke an auto-reactive immune response. The focus of this manuscript is to review the evidence that the blood-testis-barrier (BTB)/Sertoli cell (SC) barrier along with the SCs ability to modulate the immune response is vital for protecting auto-antigenic germ cells. In normal testis, the BTB/SC barrier protects the majority of the auto-antigenic germ cells by limiting access by the immune system and sequestering these 'new antigens'. SCs also modulate testis immune cells (induce regulatory immune cells) by expressing several immunoregulatory factors, thereby creating a local tolerogenic environment optimal for survival of nonsequesetred auto-antigenic germ cells. Collectively, the fortress created by the BTB/SC barrier along with modulation of the immune response is pivotal for completion of spermatogenesis and species survival. |*Spermatogenesis [MESH] |Animals [MESH] |Autoantigens/immunology/metabolism [MESH] |Autoimmunity [MESH] |Blood-Testis Barrier/*immunology [MESH] |Humans [MESH] |Male [MESH] |Peripheral Tolerance [MESH] |Sertoli Cells/*immunology/physiology [MESH] |Spermatozoa/immunology/metabolism [MESH]Sertoli cells--immunological sentinels of spermatogenesis (epmc).pdf DeepDyve Pubget Overpricing