Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28407799
.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 BMC+Nephrol
2017 ; 18
(1
): 133
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Seroprevalence of a "new" bacterium, Simkania negevensis, in renal transplant
recipients and in hemodialysis patients
#MMPMID28407799
Angeletti A
; Biondi R
; Battaglino G
; Cremonini E
; Comai G
; Capelli I
; Donati G
; Cevenini R
; Donati M
; La Manna G
BMC Nephrol
2017[Apr]; 18
(1
): 133
PMID28407799
show ga
BACKGROUND: Simkania negevensis is an obligate intracellular bacterium belonging
to the family Simkaniaceae in the Chlamydiales order. It is considered an
ubiquitous microorganism and aquatic environments may be involved as a source of
infection for humans. It was just isolated in samples from domestic water
supplies and from mains water supplies, like spa water or swimming pool water,
confirming its ability to resist to the common chlorination treatments. Evidence
indicates a possible role of the microorganism in respiratory tract infections,
in gastroenteric disorders and in the pathogenesis of cardiovascular disease,
furthermore it has hypothesized that it could play a role in lung transplant
rejection. Prevalence and possible effects in nephrology are unknown. METHODS: We
examined the occurrence of Simkania negevensis in two differents populations,
both characterized by a high susceptibility to infectious complications: 105
hemodialysis patients, 105 renal transplant recipients and 105 healthy subjects
through the IgG and IgA response to Simkania negevensis in their sera. Serum
antibodies to Simkania negevensis were detected by a homemade ELISA performed
according to the Kahane's protocol. Furthermore water samples from hemodialytic
circuit were collected, to evaluate Simkania negevensis resistance to usual
treatment of disinfection. RESULTS: Our results were unexpected, showing a higher
seroprevalence of antibodies against Simkania negevensis in the hemodialysis
patients, compared to renal transplant patients (IgG 22% vs 9% - IgA 9% vs 3%).
S. negevensis was isolated in all water samples analyzed. CONCLUSIONS: Our study
detected for the first time the occurrence of S. negevensis in hemodialysis and
in renal transplant patients. Our findings suggest that water used in
hemodialysis could be one of the possible sources of S. negevensis infection,
without clinical involvement risk for patients.