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2015 ; 42
(2
): 191-206
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English Wikipedia
Serodiagnosis for tumor viruses
#MMPMID25843726
Morrison BJ
; Labo N
; Miley WJ
; Whitby D
Semin Oncol
2015[Apr]; 42
(2
): 191-206
PMID25843726
show ga
The known human tumor viruses include the DNA viruses Epstein-Barr virus (EBV),
Kaposi sarcoma herpesvirus (KSHV), Merkel cell polyomavirus (MCPyV), human
papillomavirus (HPV), and hepatitis B virus (BV). RNA tumor viruses include human
T-cell lymphotrophic virus type 1 (HTLV-1) and hepatitis C virus (HCV). The
serological identification of antigens/antibodies in serum is a rapidly
progressing field with utility for both scientists and clinicians. Serology is
useful for conducting seroepidemiology studies and to inform on the pathogenesis
and host immune response to a particular viral agent. Clinically, serology is
useful for diagnosing current or past infection and for aiding in clinical
management decisions. Serology is useful for screening blood donations for
infectious agents and for monitoring the outcome of vaccination against these
viruses. Serodiagnosis of human tumor viruses has improved in recent years with
increased specificity and sensitivity of the assays, as well as reductions in
cost and the ability to assess multiple antibody/antigens in single assays.
Serodiagnosis of tumor viruses plays an important role in our understanding of
the prevalence and transmission of these viruses and ultimately in the ability to
develop treatments/preventions for these globally important diseases.