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2016 ; 4
(ä): 127
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Septins and Bacterial Infection
#MMPMID27891501
Torraca V
; Mostowy S
Front Cell Dev Biol
2016[]; 4
(ä): 127
PMID27891501
show ga
Septins, a unique cytoskeletal component associated with cellular membranes, are
increasingly recognized as having important roles in host defense against
bacterial infection. A role for septins during invasion of Listeria monocytogenes
into host cells was first proposed in 2002. Since then, work has shown that
septins assemble in response to a wide variety of invasive bacterial pathogens,
and septin assemblies can have different roles during the bacterial infection
process. Here we review the interplay between septins and bacterial pathogens,
highlighting septins as a structural determinant of host defense. We also discuss
how investigation of septin assembly in response to bacterial infection can yield
insight into basic cellular processes including phagocytosis, autophagy, and
mitochondrial dynamics.