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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Semin+Nephrol
2015 ; 35
(1
): 2-11
Nephropedia Template TP
Semin Nephrol
2015[Jan]; 35
(1
): 2-11
PMID25795495
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Acute kidney injury (AKI) is an epidemic problem. Sepsis has long been recognized
as a foremost precipitant of AKI. Sepsis-associated AKI (SA-AKI) portends a high
burden of morbidity and mortality in both children and adults with critical
illness. Although our understanding of its pathophysiology is incomplete, SA-AKI
likely represents a distinct subset of AKI contributed to by a unique
constellation of hemodynamic, inflammatory, and immune mechanisms. SA-AKI poses
significant clinical challenges for clinicians. To date, no singular effective
therapy has been developed to alter the natural history of SA-AKI. Rather,
current strategies to alleviate poor outcomes focus on clinical risk
identification, early detection of injury, modifying clinician behavior to avoid
harm, early appropriate antimicrobial therapy, and surveillance among survivors
for the longer-term sequelae of kidney damage. Recent evidence has confirmed that
patients no longer die with AKI, but from AKI. To improve the care and outcomes
for sufferers of SA-AKI, clinicians need a robust appreciation for its
epidemiology and current best-evidence strategies for prevention and treatment.
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