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2016 ; 10
(ä): 24
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Sensorimotor Integration by Corticospinal System
#MMPMID27013985
Moreno-López Y
; Olivares-Moreno R
; Cordero-Erausquin M
; Rojas-Piloni G
Front Neuroanat
2016[]; 10
(ä): 24
PMID27013985
show ga
The corticospinal (CS) tract is a complex system which targets several areas of
the spinal cord. In particular, the CS descending projection plays a major role
in motor command, which results from direct and indirect control of spinal cord
pre-motor interneurons as well as motoneurons. But in addition, this system is
also involved in a selective and complex modulation of sensory feedback. Despite
recent evidence confirms that CS projections drive distinct segmental neural
circuits that are part of the sensory and pre-motor pathways, little is known
about the spinal networks engaged by the corticospinal tract (CST), the
organization of CS projections, the intracortical microcircuitry, and the
synaptic interactions in the sensorimotor cortex (SMC) that may encode different
cortical outputs to the spinal cord. Here is stressed the importance of
integrated approaches for the study of sensorimotor function of CS system, in
order to understand the functional compartmentalization and hierarchical
organization of layer 5 output neurons, who are key elements for motor control
and hence, of behavior.