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2014 ; 12
(22
): 3544-61
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Self-assembly of peptides to nanostructures
#MMPMID24756480
Mandal D
; Nasrolahi Shirazi A
; Parang K
Org Biomol Chem
2014[Jun]; 12
(22
): 3544-61
PMID24756480
show ga
The formation of well-ordered nanostructures through self-assembly of diverse
organic and inorganic building blocks has drawn much attention owing to their
potential applications in biology and chemistry. Among all organic building
blocks, peptides are one of the most promising platforms due to their
biocompatibility, chemical diversity, and resemblance to proteins. Inspired by
the protein assembly in biological systems, various self-assembled peptide
structures have been constructed using several amino acids and sequences. This
review focuses on this emerging area, the recent advances in peptide
self-assembly, and formation of different nanostructures, such as tubular
structures, fibers, vesicles, and spherical and rod-coil structures. While
different peptide nanostructures have been discovered, potential applications are
explored in drug delivery, tissue engineering, wound healing, and surfactants.