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10.3389/fphys.2016.00112

http://scihub22266oqcxt.onion/10.3389/fphys.2016.00112
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C4814514!4814514 !27065880
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suck abstract from ncbi


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pmid27065880
      Front+Physiol 2016 ; 7 (ä): 112
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  • Self-Organization of Blood Pressure Regulation: Experimental Evidence #MMPMID27065880
  • Fortrat JO ; Levrard T ; Courcinous S ; Victor J
  • Front Physiol 2016[]; 7 (ä): 112 PMID27065880 show ga
  • Blood pressure regulation is a prime example of homeostatic regulation. However, some characteristics of the cardiovascular system better match a non-linear self-organized system than a homeostatic one. To determine whether blood pressure regulation is self-organized, we repeated the seminal demonstration of self-organized control of movement, but applied it to the cardiovascular system. We looked for two distinctive features peculiar to self-organization: non-equilibrium phase transitions and hysteresis in their occurrence when the system is challenged. We challenged the cardiovascular system by means of slow, 20-min Tilt-Up and Tilt-Down tilt table tests in random order. We continuously determined the phase between oscillations at the breathing frequency of Total Peripheral Resistances and Heart Rate Variability by means of cross-spectral analysis. We looked for a significant phase drift during these procedures, which signed a non-equilibrium phase transition. We determined at which head-up tilt angle it occurred. We checked that this angle was significantly different between Tilt-Up and Tilt-Down to demonstrate hysteresis. We observed a significant non-equilibrium phase transition in nine healthy volunteers out of 11 with significant hysteresis (48.1 ± 7.5° and 21.8 ± 3.9° during Tilt-Up and Tilt-Down, respectively, p < 0.05). Our study shows experimental evidence of self-organized short-term blood pressure regulation. It provides new insights into blood pressure regulation and its related disorders.
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