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2016 ; 7
(ä): 112
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Self-Organization of Blood Pressure Regulation: Experimental Evidence
#MMPMID27065880
Fortrat JO
; Levrard T
; Courcinous S
; Victor J
Front Physiol
2016[]; 7
(ä): 112
PMID27065880
show ga
Blood pressure regulation is a prime example of homeostatic regulation. However,
some characteristics of the cardiovascular system better match a non-linear
self-organized system than a homeostatic one. To determine whether blood pressure
regulation is self-organized, we repeated the seminal demonstration of
self-organized control of movement, but applied it to the cardiovascular system.
We looked for two distinctive features peculiar to self-organization:
non-equilibrium phase transitions and hysteresis in their occurrence when the
system is challenged. We challenged the cardiovascular system by means of slow,
20-min Tilt-Up and Tilt-Down tilt table tests in random order. We continuously
determined the phase between oscillations at the breathing frequency of Total
Peripheral Resistances and Heart Rate Variability by means of cross-spectral
analysis. We looked for a significant phase drift during these procedures, which
signed a non-equilibrium phase transition. We determined at which head-up tilt
angle it occurred. We checked that this angle was significantly different between
Tilt-Up and Tilt-Down to demonstrate hysteresis. We observed a significant
non-equilibrium phase transition in nine healthy volunteers out of 11 with
significant hysteresis (48.1 ± 7.5° and 21.8 ± 3.9° during Tilt-Up and Tilt-Down,
respectively, p < 0.05). Our study shows experimental evidence of self-organized
short-term blood pressure regulation. It provides new insights into blood
pressure regulation and its related disorders.