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10.1152/physrev.00039.2013 http://scihub22266oqcxt.onion/10.1152/physrev.00039.2013 C4101630!4101630 !24987004     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\24987004 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Physiol+Rev 2014 ; 94 (3 ): 739-77 Nephropedia Template TP {{tp|p=24987004 |t=2014. Selenoproteins: molecular pathways and physiological roles |pdf=|usr=}}{{24987004 }} gab.com Text Selenoproteins: molecular pathways and physiological roles JO: Physiol Rev http://www.kidney.de/pget.php?&tw=1&pmid=24987004 #FOAvip Selenium is an essential micronutrient with important functions in human health and relevance to several pathophysiological conditions. The biological effects of selenium are largely mediated by selenium-containing proteins (selenoproteins) that are present in all three domains of life. Although selenoproteins represent diverse molecular pathways and biological functions, all these proteins contain at least one selenocysteine (Sec), a selenium-containing amino acid, and most serve oxidoreductase functions. Sec is cotranslationally inserted into nascent polypeptide chains in response to the UGA codon, whose normal function is to terminate translation. To decode UGA as Sec, organisms evolved the Sec insertion machinery that allows incorporation of this amino acid at specific UGA codons in a process requiring a cis-acting Sec insertion sequence (SECIS) element. Although the basic mechanisms of Sec synthesis and insertion into proteins in both prokaryotes and eukaryotes have been studied in great detail, the identity and functions of many selenoproteins remain largely unknown. In the last decade, there has been significant progress in characterizing selenoproteins and selenoproteomes and understanding their physiological functions. We discuss current knowledge about how these unique proteins perform their functions at the molecular level and highlight new insights into the roles that selenoproteins play in human health. Twit Text FOAVip Selenoproteins: molecular pathways and physiological roles ????Physiol Rev http://www.kidney.de/pget.php?&tw=1&pmid=24987004 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24987004 #FOAvip English Wikipedia <ref>{{Cite pmid|24987004 }}</ref> Selenoproteins: molecular pathways and physiological roles #MMPMID24987004 Labunskyy VM ; Hatfield DL ; Gladyshev VN Physiol Rev 2014[Jul]; 94 (3 ): 739-77 PMID24987004 show ga Selenium is an essential micronutrient with important functions in human health and relevance to several pathophysiological conditions. The biological effects of selenium are largely mediated by selenium-containing proteins (selenoproteins) that are present in all three domains of life. Although selenoproteins represent diverse molecular pathways and biological functions, all these proteins contain at least one selenocysteine (Sec), a selenium-containing amino acid, and most serve oxidoreductase functions. Sec is cotranslationally inserted into nascent polypeptide chains in response to the UGA codon, whose normal function is to terminate translation. To decode UGA as Sec, organisms evolved the Sec insertion machinery that allows incorporation of this amino acid at specific UGA codons in a process requiring a cis-acting Sec insertion sequence (SECIS) element. Although the basic mechanisms of Sec synthesis and insertion into proteins in both prokaryotes and eukaryotes have been studied in great detail, the identity and functions of many selenoproteins remain largely unknown. In the last decade, there has been significant progress in characterizing selenoproteins and selenoproteomes and understanding their physiological functions. We discuss current knowledge about how these unique proteins perform their functions at the molecular level and highlight new insights into the roles that selenoproteins play in human health. |Animals [MESH] |Dipeptides/biosynthesis [MESH] |Humans [MESH] |Organoselenium Compounds [MESH] |Selenium/metabolism [MESH]Selenoproteins: molecular pathways and physiological roles (epmc).pdf DeepDyve Pubget Overpricing