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2016 ; 291
(46
): 24036-24040
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English Wikipedia
Selenoprotein Gene Nomenclature
#MMPMID27645994
Gladyshev VN
; Arnér ES
; Berry MJ
; Brigelius-Flohé R
; Bruford EA
; Burk RF
; Carlson BA
; Castellano S
; Chavatte L
; Conrad M
; Copeland PR
; Diamond AM
; Driscoll DM
; Ferreiro A
; Flohé L
; Green FR
; Guigó R
; Handy DE
; Hatfield DL
; Hesketh J
; Hoffmann PR
; Holmgren A
; Hondal RJ
; Howard MT
; Huang K
; Kim HY
; Kim IY
; Köhrle J
; Krol A
; Kryukov GV
; Lee BJ
; Lee BC
; Lei XG
; Liu Q
; Lescure A
; Lobanov AV
; Loscalzo J
; Maiorino M
; Mariotti M
; Sandeep Prabhu K
; Rayman MP
; Rozovsky S
; Salinas G
; Schmidt EE
; Schomburg L
; Schweizer U
; Simonovi? M
; Sunde RA
; Tsuji PA
; Tweedie S
; Ursini F
; Whanger PD
; Zhang Y
J Biol Chem
2016[Nov]; 291
(46
): 24036-24040
PMID27645994
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The human genome contains 25 genes coding for selenocysteine-containing proteins
(selenoproteins). These proteins are involved in a variety of functions, most
notably redox homeostasis. Selenoprotein enzymes with known functions are
designated according to these functions: TXNRD1, TXNRD2, and TXNRD3 (thioredoxin
reductases), GPX1, GPX2, GPX3, GPX4, and GPX6 (glutathione peroxidases), DIO1,
DIO2, and DIO3 (iodothyronine deiodinases), MSRB1 (methionine sulfoxide reductase
B1), and SEPHS2 (selenophosphate synthetase 2). Selenoproteins without known
functions have traditionally been denoted by SEL or SEP symbols. However, these
symbols are sometimes ambiguous and conflict with the approved nomenclature for
several other genes. Therefore, there is a need to implement a rational and
coherent nomenclature system for selenoprotein-encoding genes. Our solution is to
use the root symbol SELENO followed by a letter. This nomenclature applies to
SELENOF (selenoprotein F, the 15-kDa selenoprotein, SEP15), SELENOH
(selenoprotein H, SELH, C11orf31), SELENOI (selenoprotein I, SELI, EPT1), SELENOK
(selenoprotein K, SELK), SELENOM (selenoprotein M, SELM), SELENON (selenoprotein
N, SEPN1, SELN), SELENOO (selenoprotein O, SELO), SELENOP (selenoprotein P, SeP,
SEPP1, SELP), SELENOS (selenoprotein S, SELS, SEPS1, VIMP), SELENOT
(selenoprotein T, SELT), SELENOV (selenoprotein V, SELV), and SELENOW
(selenoprotein W, SELW, SEPW1). This system, approved by the HUGO Gene
Nomenclature Committee, also resolves conflicting, missing, and ambiguous
designations for selenoprotein genes and is applicable to selenoproteins across
vertebrates.
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