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10.1038/s41598-017-00231-7 http://scihub22266oqcxt.onion/10.1038/s41598-017-00231-7 C5428050!5428050 !28273949     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28273949 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28273949 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Sci+Rep 2017 ; 7 (1 ): 147 Nephropedia Template TP {{tp|p=28273949 |t=2017. Selenocystine against methyl mercury cytotoxicity in HepG2 cells |pdf=|usr=}}{{28273949 }} gab.com Text Selenocystine against methyl mercury cytotoxicity in HepG2 cells JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=28273949 #FOAvip Methyl mercury (MeHg) is a highly toxic substance and the effect of selenium against MeHg toxicity is a hot topic. Until now, no related works have been reported from the view of the point of elemental speciation which is promising to study the mechanism at the molecular level. In this work, to reveal the effect of selenocystine (SeCys(2)) against MeHg cytotoxicity in HepG2 cells, a comprehensive analytical platform for speciation study of mercury and selenium in MeHg incubated or MeHg and SeCys(2) co-incubated HepG2 cells was developed by integrating liquid chromatography (LC) - inductively coupled plasma mass spectrometry (ICP-MS) hyphenated techniques and chip-based pretreatment method. Interesting phenomenon was found that the co-incubation of MeHg with SeCys(2) promoted the uptake of MeHg in HepG2 cells, but reduced the cytotoxicity of MeHg. Results obtained by ICP-MS based hyphenated techniques revealed a possible pathway for the incorporation and excretion of mercury species with the coexistence of SeCys(2). The formation of MeHg and SeCys(2) aggregation promotes the uptake of MeHg; majority of MeHg transforms into small molecular complexes (MeHg-glutathione (GSH) and MeHg-cysteine (Cys)) in HepG2 cells; and MeHg-GSH is the elimination species which results in reducing the cytotoxicity of MeHg. Twit Text FOAVip Selenocystine against methyl mercury cytotoxicity in HepG2 cells ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=28273949 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28273949 #FOAvip English Wikipedia <ref>{{Cite pmid|28273949 }}</ref> Selenocystine against methyl mercury cytotoxicity in HepG2 cells #MMPMID28273949 Wang H ; Chen B ; He M ; Yu X ; Hu B Sci Rep 2017[Mar]; 7 (1 ): 147 PMID28273949 show ga Methyl mercury (MeHg) is a highly toxic substance and the effect of selenium against MeHg toxicity is a hot topic. Until now, no related works have been reported from the view of the point of elemental speciation which is promising to study the mechanism at the molecular level. In this work, to reveal the effect of selenocystine (SeCys(2)) against MeHg cytotoxicity in HepG2 cells, a comprehensive analytical platform for speciation study of mercury and selenium in MeHg incubated or MeHg and SeCys(2) co-incubated HepG2 cells was developed by integrating liquid chromatography (LC) - inductively coupled plasma mass spectrometry (ICP-MS) hyphenated techniques and chip-based pretreatment method. Interesting phenomenon was found that the co-incubation of MeHg with SeCys(2) promoted the uptake of MeHg in HepG2 cells, but reduced the cytotoxicity of MeHg. Results obtained by ICP-MS based hyphenated techniques revealed a possible pathway for the incorporation and excretion of mercury species with the coexistence of SeCys(2). The formation of MeHg and SeCys(2) aggregation promotes the uptake of MeHg; majority of MeHg transforms into small molecular complexes (MeHg-glutathione (GSH) and MeHg-cysteine (Cys)) in HepG2 cells; and MeHg-GSH is the elimination species which results in reducing the cytotoxicity of MeHg. |Cell Proliferation [MESH] |Cell Survival [MESH] |Chromatography, Liquid [MESH] |Cystine/*analogs & derivatives/pharmacology [MESH] |Hep G2 Cells [MESH] |Humans [MESH] |Mass Spectrometry [MESH] |Mercury/*analysis [MESH] |Methylmercury Compounds/*toxicity [MESH]Selenocystine against methyl mercury cytotoxicity in HepG2 cells (epmc).pdf DeepDyve Pubget Overpricing