Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28255299
&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests
in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215
Selenium and Thyroid Disease: From Pathophysiology to Treatment
#MMPMID28255299
Ventura M
; Melo M
; Carrilho F
Int J Endocrinol
2017[]; 2017
(?): 1297658
PMID28255299
show ga
Introduction. Selenium is a micronutrient embedded in several proteins. In
adults, the thyroid is the organ with the highest amount of selenium per gram of
tissue. Selenium levels in the body depend on the characteristics of the
population and its diet, geographic area, and soil composition. In the thyroid,
selenium is required for the antioxidant function and for the metabolism of
thyroid hormones. Methods. We performed a review of the literature on selenium's
role in thyroid function using PubMed/MEDLINE. Results. Regarding thyroid
pathology, selenium intake has been particularly associated with autoimmune
disorders. The literature suggests that selenium supplementation of patients with
autoimmune thyroiditis is associated with a reduction in antithyroperoxidase
antibody levels, improved thyroid ultrasound features, and improved quality of
life. Selenium supplementation in Graves' orbitopathy is associated with an
improvement of quality of life and eye involvement, as well as delayed
progression of ocular disorders. The organic form of selenium seems to be the
preferable formulation for supplementation or treatment. Conclusion. Maintaining
a physiological concentration of selenium is a prerequisite to prevent thyroid
disease and preserve overall health. Supplementation with the organic form is
more effective, and patients with autoimmune thyroiditis seem to have benefits in
immunological mechanisms. Selenium supplementation proved to be clinically
beneficial in patients with mild to moderate Graves' orbitopathy.
free
free
free
